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Sinonasal undifferentiated carcinoma SNUC

TABLE 9.4 Olfactory Neuroblastoma (ONB) versus Sinonasal Undifferentiated Carcinoma (SNUC) ... [Pg.264]

CK, cytokeratin EMA, epithelial membrane antigen LCA, leukocyte common antigen NPC, nasopharyngeal carcinoma ONE, olfactory neuroblastoma ES/PNET, Ewing s sarcoma/peripheral neuroectodermal tumor SNUC, sinonasal undifferentiated carcinoma. [Pg.262]

NKSCC, nonkeratinizing squamous cell carcinoma NPTC, nasopharyngeal-type undifferentiated carcinoma SCC, squamous cell carcinoma SNUC, sinonasal undifferentiated carcinoma. [Pg.264]

A recent study of SNUCs at the molecular level has revealed an interesting mutation in a subset of these tumors. Approximately 20% of undifferentiated tumors of the upper aerodigestive tract (including some in the sinonasal tract) were positive for the NUT-BRD4 translocation. These tumors tended to have an unusual morphologic appearance with abrupt keratinization and often had p63 positivity. This translocation was previously seen only in what were termed central lethal carcinomas. The diagnostic and potential therapeutic applications of testing for the translocation are not well understood at this point. [Pg.269]

See other pages where Sinonasal undifferentiated carcinoma SNUC is mentioned: [Pg.271]    [Pg.271]    [Pg.264]   
See also in sourсe #XX -- [ Pg.264 , Pg.264 , Pg.265 ]



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