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Silent information regulator

Hecht, A., Laroche, T., Strahl-Bosinger, S., Gasser, S.M., and Grunstein, M. (1995) Histone H3 and H4 N-termini interact with the Silent Information Regulators Sir3 and Sir4 a molecular model for the formation of heterochromatin in yeast. Cell 80, 583-592. [Pg.307]

The sirtuins (silent information regulator 2-related proteins class III HDACs) form a specific class of histone deacetylases. First, they do not share any sequence or structural homology with the other HDACs. Second, they do not require zinc for activity, but rather use the oxidized form of nicotinamide adenine dinucleotide (NAD ) as cofactor. The reaction catalyzed by these enzymes is the conversion of histones acetylated at specific lysine residues into deacetylated histones, the other products of the reaction being nicotinamide and the metabolite 2 -0-acetyl-adenosine diphosphate ribose (OAADPR) [51, 52]. As HATs and other HDACs, sirtuins not only use acetylated histones as substrates but can also deacetylate other proteins. Intriguingly, some sirtuins do not display any deacetylase activity but act as ADP-ribosyl transferases. [Pg.34]

Heltweg, B., Gatbonton, T, Schuler, A.D., Posakony, J., Li, H., Goehle, S. etal. (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research, 66, 4368-4377. [Pg.84]

Tanner, K.G., Landry, J., Sternglanz, R. and Denu, J.M. (2000) Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proceedings of the National Academy of Sciences of the United States of America, 97, 14178-14182. [Pg.237]

Schwer, B., North, B.J., Frye, R.A., Ott, M. and Verdin, E. (2002) The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinudeotide-dependent deacetylase. The Journal of Cell Biology, 158, 647-657. [Pg.238]

RAAS, renin, angiotensin, aldosterone system SCD-1, stearoyl-CoA desaturase 1 Sirtl, silent information regulator 1... [Pg.1027]

SIR = silent information regulator deacetylase (activator) of p53 promoter SZ = Szeged, 6726 Hungary for Drosophila Stock Center, Molecular Biology, University of Szeged... [Pg.104]

Mammalian sirtuins (SIRTs, silent information regulator transcript) were identified as conserved structural homologues to the yeast silent information regulator protein (Sir2), which has been shown to mediate longevity under calorie restriction conditions. The increased lifespan associated with calorie restriction in general has been attributed to reduced rates of cancer, diabetes, inflammation, and cardiovascular... [Pg.202]

See other pages where Silent information regulator is mentioned: [Pg.338]    [Pg.269]    [Pg.424]    [Pg.225]    [Pg.5120]    [Pg.402]    [Pg.413]    [Pg.46]    [Pg.696]    [Pg.5119]    [Pg.98]    [Pg.144]    [Pg.98]    [Pg.413]    [Pg.135]    [Pg.86]    [Pg.339]    [Pg.342]    [Pg.516]    [Pg.643]    [Pg.156]    [Pg.507]    [Pg.276]   
See also in sourсe #XX -- [ Pg.225 ]



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