Signalling Transducers

Signal-transducing receptors are plasma membrane proteins that bind specific molecules, such as growth factors, hormones, or neurotransmitters, and then transmit a signal to the cell s interior, causing the cell to respond in a... 

The ankyrin repeat motif is one of the most common protein-protein interaction domains. Ankyrin repeats are modules of about 33 amino acids repeated in tandem. They are found in a large number of proteins with diverse cellular functions such as transcriptional regulators, signal transducers, cell-cycle regulators, and cytoskeletal proteins. 

Tumor necrosis factor receptor associated factors are a group of at least 6 proteins (TRAF 1-6), which are major signal transducers for the TNF receptor superfamily and the the interlukin-1 receptor/toll-like receptor (IL-1R/ TLR) superfamily. TRAF proteins are characterized by the presence of the TRAF domain at the the C-terminus,... 

Indicator electrodes are used both for analytical purposes (in determining the concentrations of different substances from values of the open-circuit potential or from characteristic features of the polarization curves) and for the detection and quantitative characterization of various phenomena and processes (as electrochemical sensors or signal transducers). One variety of indicator electrode are the reference electrodes, which have stable and reproducible values of potential and thus can be used to measure the potentials of other electrodes. 

The murine stromal-derived factor-la (SDF-1)/CXCL12 was originally cloned from a cDNA library derived from the bone marrow stromal cell tine ST2 by a method to clone cDNAs that carry specific amino terminal signal sequences, such as those encoding intercellular signaling-transducing molecules... 

Wood, K. W Samecki, C., Roberts, T. M and Blenis, J. (1992). ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases MAP kinase, Raf-1, and RSK. Cell 68 1041-1050. 

G-proteins are trimeric, signal-transducing, guanine nucleotide-binding proteins. They constitute the first step in transducing the agonist-induced activation of a G-protein-coupled receptor (see Chapter 2) to a cellular response. 

---