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Signal Transducer and Activator of Transcription

STAT1 is activated by various ligands including cytokines, IFN-a, IFN-y, IL-4, IL-5, IL-13, growth factors and hormones. It has four conserved domains N-terminal, C-terminal, SH2 domain and DNA-binding domain, which is typical of all STAT family members. The SH2 domain is distinct for each STAT and a stable SH2-phosphotyrosine bond is formed after the SH2 domain binds to its specific phosphotyrosine domain. This SH2-pTyr bond is responsible for STAT activation [Pg.66]

STAT Ligand STAT Deficiency-Associated Human Disease [Pg.66]

STAT1 IFN Alzheimer s disease, cancer, celiac disease, ischemic heart disease, Inflammatory Bowel Disease (IBD), rheumatoid arthritis [Pg.66]

STAT4 IL-12 Chronic obstructive pulmonary disease (COPD), rheumatoid arthritis [Pg.66]

STAT5a PRL Cancer, diabetes, ischemic heart disease [Pg.66]


Ihle, J. 1996. STATs signal transducers and activators of transcription. Cell 84, 331-334. [Pg.237]

JAKs and signal transducers and activators of transcription (STATs) are functionally analogous with IRS and PI3K. JAKs are physically associated with a cell surface receptor (e.g. for leptin, erythropoietin (EPO), growth factors or cytokines) STATs are free monomeric proteins within the cytosol but following phosphorylation by a JAK, individual proteins dimerize and then move into the nucleus of the cell where they control gene expression. [Pg.115]

Leptin signalling is via monomeric receptors in the brain. A short-form of the leptin receptor (Lep-R) is required to transport the hormone across the blood-brain barrier and a long-form Lep-R is located in the hypothalamus. The long-form is functionally linked with a particular type of receptor-associated tyrosine kinase called Janus kinase (JAK, see Section 4.7) whose function is to phosphorylate a STAT (signal transducer and activator of transcription) protein a similar mechanism to that often associated with signalling by inflammatory cytokines. [Pg.307]

STAT-3 Signal transducer and activator of transcription-3 VEGFR Vascular endothelial growth factor receptor... [Pg.384]


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Activated transcription

Activation and signaling

Activation of Transcription

Activators transcription

Janus kinase-signal transducers and activators of transcription

Janus kinase-signal transducers and activators of transcription JAK-STAT)

Signal transducers and activators

Signal transducers and activators of transcription STAT)

Signal transducers and activators of transcription STATs)

Signal transducers and activators transcription

Signaling activation

Signalling Transducers

The Janus Family Tyrosine Kinases-Signal Transducers and Activators of Transcription Signaling Pathway

Transcription activation

Transcriptional activation

Transcriptional activator

Transducer, transducers

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