Allergic disease signal transducers

Chen W, Hershey GKK. 2007. Signal transducer and activator of transcription signals in allergic disease. J. Allergy Clin Immunol. 119 529-541. 

The Role of Signal Transducers and Activators of Transcription in Allergic Disease... 

Antihistamines, or Hi receptor antagonists, have an established and valued place in the symptomatic treatment of the manifestations of allergic disease and can be administered orally, nasally, or as eye drops. The Hi histamine receptor is a heptahelical transmembrane molecule that transduces extracellular signals to intracellular second messenger systems via G proteins. Hi antihistamines act as inverse agonists that combine with the Hi receptor, stabilizing it in the inactive form and shifting the equilibrium toward the inactive state [1 ]. 

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