Stability short-term

B. Kerwin, M. Heller, S. Levin, and T. Randolph, Effect of Tween 80 and sucrose on acute short-term stability and long trem storage at — 20° C of a recombinant hemoglobin, J. Pharm. Sci., 87, 1062 (1998). 

Another commercial thermistor, Thermox (by LakeShore), is useful between 77 K (—80kfl) and room temperature (—0.3 fi). It consists of a glass-encapsulated metal oxide bead. The short-term stability is about 25 mK in the useful range. 

Studies with the freeze dried DPPC liposomes in trehalose solution showed, that not Tg )f the amorphous sugar is the critical temperature during storage, but the bilayer transition emperature Tm. for the lyposomes determines the short term stability of the formulation. With trehalose as lyoprotectant and a low residual water content, Tm proved to be 10 to 30 °C below the onset of T . 30 min heating above Tm but well below T% decreased the retention of CF after rehydration. Tm< after the heating was reduced from 40 to 80 °C to below 25 °C. 

Cast multibilayers prepared from an azobenzene-containing surfactant (33) [426] and from mixtures of 33 and 5 display only short-term stabilities and low solubilities in water. These disadvantages have been overcome by coating the multibilayers with cellulose acetate and by using poly(vinyl alcohol) as a binder [429], The method of choice in preparing these composite cast multibilayers... 

Polymeric materials used for electrical insulation not only have to exhibit good electrical properties, but good mechanical properties and good appearance are also important. In addition to reliable electrical performance, thermal stability is important, mainly for miniaturized electronic and electrical equipment. Long-term stability at temperatures in the range between 90 to 125°C (194 to 257°F) is required and the short-term stability determines the resistance to melted solder and cut-through resistance. 

The short-term stability study is conducted over extreme environmental conditions to increase the rate of chemical degradation. The data obtained from short-term stability studies are normally used to evaluate longer term chemical effects at nonextreme storage conditions, but they are also helpful to assess the effect of shortterm excursions outside the recommended storage conditions that might occur during shipping. However, the results from short-term stability studies cannot always... 

A short-term stability study is conducted under stressed conditions to increase the rate of chemical and physical degradation of the drug product. The classical statistical procedure to establish a preliminary shelf life is based on regression techniques, which are used to estimate the parameters of the Arrhenius equation. 

Any solid waste form should serve to reduce waste volume and provide short term stabilization under conditions such as fracture, fire, or water immersion which could result from a transportation mishap. In the geologic storage scenarios currently receiving the most scrutiny, the most likely path to the biosphere has been identified as aqueous transport of nuclides via groundwater. Thus an acceptable waste form would also resist dissolution under ambient repository conditions, with the obvious benefit of assuring a sufficiently low nuclide release rate into an aquifer to preclude a significant threat to health and safety. 

The light sources used for CD measurements must be intense and should possess good short-term stability. Synchrotron radiation promises to be an excellent source of radiation for CD measurements in the wavelength range from vacuum ultraviolet to infrared 247, 248). 

When instability is detected at an earlier stage of study the material has to be immediately stored in adequate conditions. In addition a short-term stability study has to be performed to monitor the behaviour of the material during transport under possibly increased temperature conditions. Short-term drastic transport conditions maybe reproduced by storing the material under temperatures up to 40-50°C for 10 days. This covers the maximum real-time transport duration (normal surface transportation) under severe high temperatures (Quevauviller, 1998b). 

The repeatability and short-term stability of the NDIR analyzers used at IMGC, i.e., Hartmann and Braun s URAS 10E, were tested in a previous work [1]. A procedure for calibrating NDIR analyzers with WRMs has been developed, which requires seven calibration points to establish the relationship between the analyzer output and the analyte concentration in the whole concentration range of interest. Since the traceability of measurements around the average C02 concentration is of particular... 

Most of the reference electrodes embedded in concrete are used for control of cathodic protection (CP) systems. Potential stability is then less important, compared to corrosion state monitoring. Control of CP systems requires only short-term stability, maximum 24 hours. Corrosion rate measurement, like linear polarisation resistance (LPR) measurements, also requires short-term reference electrode stability. However, regardless of application, a reference electrode which is to be permanently embedded in the test solution, e.g. concrete, must have a long life when exposed to this environment. 

Bioanalytical method validation criteria should be applied to analytical methods whenever possible. It was also decided that long-term storage stability was not necessary, although short-term stability should be demonstrated. 

The potentiometer is the classical instrument for the precise measurement of voltage. In a simple student potentiometer, the precision depends on the precision of the individual resistance elements and the linearity of the slidewire. The measurement accuracy depends on the short-term stability of the battery or power-supply voltage, although slow drifts can be compensated by frequent iestandaidization. 

With IR light sources like this one, a technology is available which, in terms of day-to-day reliability and long-term and short-term stability, is entirely comparable with Ti sapphire regenerative amplifiers. As shown in this article, it was possible to perform femtosecond experiments on all kinds of condensed phase phenomena involving vibrational transitions (such as energy relaxation, dephasing, spectral diffusion, coupled systems) with essentially the same facility and accuracy as can be achieved in visible and near-infrared experiments. 

Rubianes and Rivas [79] reported that the oxidation of NADH at CNTPE started at -0.100 V, that is, 0.300 V less positive than at CPE due to the catalytic effect of carbon nanotubes. The CNTPE demonstrated an effective short term-stability since even after 15 min at 0.400 V, the oxidation signal of 1.0 x 10 M NADH decreased less than 20 %. In similar experiments at CPE the signal decreased more than 80 %. 

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