Physical degradation

Phospholipid hydrolysis Cholesterol autooxidation Antioxidant degradation Physical stability Vesicle size distribution submicron range... 

Moisture can also degrade physical properties and cause dimension changes of certain adherends. 

In this way one mole of water reacts with two moles of isocyanate. For a urethane prepolymer with an equivalent weight of about 300, it only takes 9 grams of water to effectively consume the prepolymer. This can lead not only to degraded physical properties, but it also forms gas bubbles in the proplnt which lead to voids and higher than predicted burning rates. This sensitivity to water content also exists with hydroxy-terminated polybutadiene polymers cured with... 

DNA and oligonucleotides provide similar challenges - large hydrophilic molecules with no propensity for movement across cell walls and prone to degradation physically and chemically. 

J. Akhter, R. Murray, K. Mahmood et al.. Improvement of Degraded Physical Properties of a Saline-Sodic Soil by Reclamation with Kallar Grass (Leptochloa fusca), Plant Soil, 258(1), 207-216, Jan. (2004). 

Decision largely dependent on the stability of the formulation and whether any degradation, physical/bioavailability changes related to moisture, oxygen, light, carbon dioxide, etc. could occur. Long-term stability data on pack appears essential and could be part of procedure prior to agreed release, i.e. check via the above tests, then do 3-6 months of a formal stability test... 

Planes, G. A., J. L. Rodriguez, M. C. Miras, G. Garcia, E. Pastor, and C. A. Barbero. 2010. Spectroscopic evidence for intermediate species formed during aniline polymerization and polyaniline degradation. Physical Chemistry Chemical Physics 12 10584-10593. 

Abrasive forces Physical degradation, physical wear, environmental stress, cracking... 

Plasticised PVC Cellulose Acetate PMMA Impact Polystyrene Polypropylene Slight degradation, physical property loss or moisture absorption... 

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