Shiga toxin-producing E. coli

Different EHEC serotypes are often found in ruminant populations, but most of the research to elucidate the effect of feed type on EHEC prevalence has been based on serotype 0157 H7. The preference for this pathogenic strain is due to its public health importance, its unique phenotypic characteristics that allow a relatively easy identification compared to other serotypes and the fact that ruminants are its most important natural reservoir. Shiga toxin-producing E. coli (STEC) are a larger group that includes EHEC and have also been found in ruminant populations in relatively large prevalence. Because the pathogenicity of most STEC has not been proven, we will focus our discussion on serotype 0157 H7. 

Bower, J. R. (1999). Foodbome diseases Shiga toxin producing E. coli (STEC). Pediatr. Infect. Dis. ]. 18,909-910. 

Weiner, M. and Osek, J. (2007). Shiga toxin producing E. coli-the actual state of knowledge. 

K. Nishikawa, K. Matsuoka, E. Kita, N. Okabe, M. Mizugushi, K. Hino, S. Miyazawa, C. Yamasaki, J. Aoki, S. Takashima, Y. Yamakawa, M. Nishijima, et al., A therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli 0157 H7, Proc. Natl. Acad. Sci. (USA), 99 (2002) 7669-7674. 

Samadapour, M., J. Liston, J.E. Ongerth, and P.I. Tarr. 1990. Evaluation of DNA probes for detection of Shiga-like-toxin-producing Escherichia coli in food and calf fecal samples. Appl. Environ. Microbiol. 56 1212-1215. 

Shiga toxin is produced (i) by Shigella cfysenterica, the cause of bacillary dysentery, (ii) by certain E. coli strains (EHEC, enterohaemorrhagic E. coli cause of the... 

Tissue culture of susceptible mammalian cells may be used to characterize some bacteria by the toxins they produce. For example, Shiga-like toxins (verotoxins) are produced by E. coli 0157 H7.4,8... 

In 1982 in the USA, two outbreaks of severe colitis were associated with eating of nndercooked meat contaminated by E. coli 0157 H7 serotype (Riley et al. 1983). Strains of this serotype were found to produce a toxin similar to that of Shigella dysenteria the shiga-toxin also called verotoxin due to its cytotoxic activity on Vero cells (KarmaU et al. 1983). 

Shiga toxin. Toxic protein produced by E. coli... 

---