Sex-linked recessive mutation

Carbon tetrachloride was not mutagenic in bacteria. It induced intra-chromosomal and mitotic recombination but not aneuploidy in Saccharomyces cerevisiae, aneuploidy was detected in another single study in Aspergillus nidulans. In vivo, in a single study with Drosophila melanogaster, no sex-linked recessive mutations were observed. 

D has been active in many different short-term genetic assays, including DNA damage and repair, mutations in yeast and human cells, sex-linked recessive mutations in fruit flies, and chromosome aberrations in vitro. 

Thioacetamide induced an increase in sex-linked recessive mutations in Drosophila. It was non-mutagenic in the SalmonellalAmes mutagenicity assay, and in the Escherichia coli recombination assay. Protein synthesis in mouse hepatoma (MH-134), but not in L-929 cells, was enhanced by adding thioacetamide. 

TK or HPRT forward mutation assays in cultured mammalian ceils Drosophila sex-linked recessive lethal assay... 

Insect systems Drosophila melanogaster (sex-linked recessive lethal test) Recessive lethal mutation + Velazquez et al. 1984... 

Sex-linked recessive lethal mutations were not produced in Drosophila fed ethanol solution containing 50 ppm 1,2-diphenylhydrazine for 3 days (Yoon et al. 1985). No oral genotoxicity studies of 1,2-diphenylhydrazine in mammals were located. 

Sex-linked recessive Drosophila melanogaster/ lethal mutation feeding... 

Vogel, E., Blijleven, W.G.H., Kortselius, M.J.H. and Zijlstra, J.A. (1981) Mutagenic activity of 17 coded compounds in the sex-linked recessive lethal test in Drosophila melanogaster, in Progress in Mutation Research, Volume 1 Evaluation of Short-Term Tests Carcinogens (eds F.J. de Serres and J. Ashby), Elsevier, Amsterdam. 

In a test for sex-linked recessive lethal mutations in Drosophila, Wild et al. 8 found no evidence of mutagenicity of CS. More than 9,000 chromosomes were tested, and the frequencies of mutations in the treated groups did not differ from those in the concurrent negative controls or the historical negative controls. The available information on the toxicity of CS under the treatment conditions is minimal. The actual dosages received by the flies are also uncertain, particularly because CS breaks down rapidly in water. Nevertheless, the available data give no indication of mutagenicity of CS in Drosophila. 

Like many other Irritants, PS has not been tested thoroughly for mutagenicity. However, in one early study, Auerbach tested its capacity to Induce sex-linked recessive lethal mutations In the fruit fly, Drosophila melanogaster. In all broods of flies derived from PS-treated males, the mutation frequencies were consistent with those of untreated laboratory stocks. A total of 4,454 chromosomes were tested, and the mutation frequency was 0.2%. In contrast, flies treated with mustard gas had a frequency of 5.2%. 

A small increase in somatic mutation frequency was reported in the eye-colour spot test with Drosophila melanogaster exposed to di(2-ethylhexyl) phthalate in the feed but no effect was observed in two independent wing-spot tests. In a single study, mitotic recombination was not induced by di(2-ethylhexyl) phthalate neither was sex-linked recessive lethal mutation induced in two studies in D. melanogaster treated with di(2-ethylhexyl) phthalate in the feed or by injection. When administered to D. melanogaster, di(2-ethylhexyl) phthalate and A-nitrosodiethylamine induced DNA double-strand breakage and DNA repair, although neither compound was active when administered alone. 

Di(2-ethylhexyl) adipate did not induce gene mutations, sister chromatid exchanges, chromosomal aberrations or micronuclei in rodent cells in vitro. It did not induce sex-linked recessive lethal mutations in Drosophila when administered either by diet or injection. Di(2-ethylhexyl) adipate was not mutagenic to either Photo-... 

Drosophila melanogaster, sex-linked recessive lethal mutations - 1267 in feed Wild el a/. (1983)... 

Sex-linked recessive lethal mutations were not induced in Drosophila melano-gaster. Coumarin did not induce either micronuclei in mice or unscheduled DNA... 

Bacillus subtilis H17 rec MA5 recT, DNA damage assay Saccharomyces cerevisiae JDl, gene conversion Drosophila melanogaster, sex-linked recessive lethal mutation Unscheduled DNA synthesis, primary rat hepatocytes in vitro Sister chromatid exchange, Chinese hamster ovary CHO cells in vitro... 

Glycidol gave a positive response in assays of prophage induction and SOS repair m Escherichia coli. Results were uniformly positive in several Salmonella typhimurium reverse mutation assays and in two fungal mutation assays. The sex-linked recessive lethal mutation assay and the heritable translocation test in Drosophila melanogaster also gave positive results. 

Drosophila melanogaster, sex-linked recessive lethal mutations... 

Butadiene did not induce somatic cell mutation and recombination or sex-linked recessive lethal mutation in Drosophila melanogaster. 

DMX, Drosophila melanogaster, sex-linked recessive leathal mutations DIA, Single-strand breaks, NMRI mouse alveolar macrophages in vitro G5T, Gene mutation, mouse lymphoma L5178Y cells, tk locus in vitro... 

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