Dictamnus dasycarpus

Dictamnus albus L. subsp. dasycarpus (Turcz.) Winter, Dictamnus dasycarpus, Fraxinella dictamnus Moench Securinega virosa (Roxb.) Pax Hoffmann Solanum lyratum Thunb., S. melongena L. 

Cneorum tricoccon (Cneoraceae), Trichilla trifola (Meliaceae), Citrus spp., Dictamnus dasycarpus (Rutaceae), Harrisonia abyssinica (Sinaroubaceae)... 

Citrus paradisi (grapefruit) Dictamnus dasycarpus (densefruit pittany)... 

Stekhun FI, Kyrnakov BA. [Dermatitis caused by Dictamnus dasycarpus.] Vestn Dermatol Venerol 196236 67-70. 

Key v/ords-Dictamnus dasycarpus, Rutaceae, sesquiterpene glycosides, dictaninosides A-E. 

Abstract—Five novel sesquiterpene glycosides named dictamnosides A-E (1-5) were isolated from the methanol extract of the root bark of Dictamnus dasycarpus (Rutaceae). Their structures were established on the basis of X-ray diffraction, spectroscopic and chemical methods. 

Plant material The root bark of Dictamnus dasycarpus was purchased from Shanghai Medicine Materia Corporation, and identified by Prof Jixian Guo of School of Pharmacy, Shanghai Medical University. A voucher specimen is deposited in the Herbarium of Shanghai Institute of Materia Medica, Chinese Academy of Sciences. 

Extraction and isolation The root bark of Dictamnus dasycarpus (3 kg) was powdered and then percolated three times with dichloromethane and methanol successively at room temperature (3x101). The filtrate was evaporated to dryness to give dichloromethane (150 g) and methanol extracts (90 g), respectively. 

Dalbergia hupeana 143 Debaryomyces hansenii 15 Decaisnea Fargesii 168,170 Dendrobium candidum 91-92,98 Desmodium styracifolium 143 Dictamnus dasycarpus 383,390 Dioscorea collettii var. hypoglauca 220,221,227... 

Wang P, Sun j b, Xu JY, Yan Q, Gao EZ, Qu W, et al. Pharmacokinetics, tissue distribution and excretion study of dictamine, a major bioactive component from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae). J Chromatogr B Analyt Tech-nol Biomed Life Sci 2013 942 1-8. 

Dasycarine 3-CH2CH = CMc2, 4,5,8-triOMe Dictamnus dasycarpus [35]... 

Boronellapancheri [28], Dictamnus dasycarpus [29], Dutaillyea baudouinii [26], Melicope semecarpifolia (= M. confusa, Euodia merrillii) [36]... 

Yang J-L, Liu L-L, Shi Y-P (2011) Limonoids and quinoline alkaloids from Dictamnus dasycarpus. Plant Med 77 271-276... 

Cortex Dictamnus dasycarpus (bai xian pi) and Radix Sophora flavescens (ku shen), is commonly used to treat hematochezia, anal bulge, and constipation caused by hemorrhoids. The State Food and Drug Administration of China (SFDA) has received several reports of adverse reactions to Zhi xue capsule in recent years [7, 8 ]. Up to September 2008, 35 cases of adverse reactions associated with Zhi xue capsule had been reported, of which 21 were associated with abnormal liver function, cholestatic hepatitis, and drug-induced liver damage. After withdrawal and symptomatic treatment, there was full recovery in eight cases, and the rest improved markedly. 

Root bark of Dictamnus albus L. var. dasy-carpus (Turcz.) T. N. Liou et Y. H. Chang (syn. Dictamnus dasycarpus Turcz.) (Family Ruta-ceae), a strong scented perennial herb, up to 1 m high, with fleshy root widely distributed in northern, northeastern and central China as well as Mongolia and Siberia. Root is dug up in spring and autumn, rid of rootlets, and washed free of dirt bark is then removed, cut in sections, and normally sun-dried. 

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