Dendrobium nobile

The dopaminergic potential of the Dendrobium species is, to date, open for exploration. An interesting feature of the Dendrobium species is their ability to elaborate sesquiterpene alkaloids, the chemical structure of which resembles the one of strychnine. One such alkaloid is dendrobine, which is widespread in the genus. Kudo et al. noted that dendrobine, isolated from Dendrobium nobile, exhibits a strychnine-like presynaptic inhibition in frog spinal cord (64). [Pg.119]

Cycloaddition reactions of furans are still widely used as key steps in the construction of complex molecules including natural products. As an example, the intramolecular Diels-Alder cycloaddition of 2-amido substituted furans provides a useful tool for the synthesis of fused, nitrogen-containing poly-heterocycles. Thus, thermolysis of 3-substituted amidofuran produces tricyclic indolinone 39 as a 2 1 mixture of diastereomers via amidofuran cycloaddition-rearrangement methodology, which serves as a key intermediate in the total synthesis of ( )-dendrobine, a major component of the Chinese ornamental orchid Dendrobium nobile . [Pg.134]

Dendrobium nobile Lindl. Shi Dou (Orchid) (stem) Dendrobine.50 Analgesic, hyperglycemic, hypotensive, hypothermic. [Pg.69]

Dendrobium nobile Lindl., Epidendrum monile Thunb. [Pg.364]

Flakinin A (7) C15H20O5 oNj/ Orchidaceae Dendrobium nobile, cultivar D. Snowflake Red Star Whole plants extracted with CH3OH yielded after repeated chromatography 2 X lQ- % Amorphous ESIMS IR H-NMR C-NMR 2D-NMR [c(]d (17)... [Pg.76]

Orchidaceae Dendrobium nobile, cultivar Snowflake Red Star ... [Pg.85]

Shu Y, Zhang DM, Guo SX (2004) A New Sesquiterpene Glycoside from Dendrobium nobile Lindl. J Asian Nat Prod Res 6 311... [Pg.199]

Ye QH, Qin GW, Zhao WM (2002) Immunomodulatory Sesquiterpene Glycosides from Dendrobium nobile. Phytochemistry 61 885... [Pg.199]

Okamoto T, Natsume M, Onaka T, Uchimaro F, Shimizu M (1972) Further Studies on the Alkaloidal Constituents of Dendrobium nobile (Orchidaceae)-Stmcture Determination of 4-Hydroxydendroxine and Nobilomethylene. Chem Pharm Bull 20 418... [Pg.200]

Zhang X, Tu FJ, Ju HY, Wang NL, Wang Z, Yao XS (2008) Copacamphane, Picrotoxane and Cyclocopacamphane Sesquiterpenes from Dendrobium nobile. Chem Pharm Bull 56 854... [Pg.200]

Zhao WM, Ye QH (2002) New Alloaromadendrane, Cadinene and Cyclocopacamphane Type Sesquiterpene Derivatives and Bibenzyls from Dendrobium nobile. Planta Med 68 723... [Pg.200]

Zhao WM, Ye Q, Tan X, Jiang H, Li X, Chen K, Kinghom AD (2001) Three New Sesquiterpene Glycosides from Dendrobium nobile with Immunomodulatory Activity. J Nat Prod 64 1196... [Pg.200]

Hedman K, Leander K (1972) Studies on Orchidaceae Alkaloids XXVII. Quaternary Salts of the Dendrobine Type from Dendrobium nobile Lindl. Acta Chem Scand 26 3177... [Pg.200]

Liu QE, Zhao WM, (2003) A New Dendrobine-Type Alkaloid from Dendrobium nobile. Chin Chem Lett 14 278... [Pg.200]

Wang H, Zhao T, Che CT (1985) Dendrobine and 3-Hydroxy-2-oxodendrobine from Dendrobium nobile. J Nat Prod 48 796... [Pg.201]

Wang SY, Song XQ, Li HH (2007) Analysis of Dendrobium nobile Lindl Produced in Yunnan and Content of Total Alkaloids Provided by Cell Culture. Guizhou Shifan Daxue Xuebao, Ziran Kexueban 25(2) 1.2, 16 CAN 2008 36071... [Pg.202]

Onaka T, Kamata S, Maeda T, Kawazoe Y, Natsume M, Okamoto T, Uchimaro F, Shimizu M (1965) The Structure of Nobilonine. The Second Alkaloid from Dendrobium nobile. Chem Pharm Bull 13 745... [Pg.203]

Information on the direct route to the copacamphane skeleton has been obtained by studies on the biosynthesis of dendrobine (39), an alkaloid found in the orchid Dendrobium nobile, and related compounds (1969, 1972, 1973). The presumed route to (39) is shown in Scheme 7 and studies with (3K,55)-[5- Hj]MVA and its (5/ )-isomer have now revealed that a 1,3-hydride shift to the side-chain (previously demonstrated in 1973) involved the same epimeric hydrogen at C-5 of MVA as shifted in the formation of sativene. [Pg.190]

The C5 trimer famesyl pyrophosphate (35), in addition to serving as a pregenitor of steroids via squalene (114), is also the pregenitor of the C15 compounds known as sesquiterpenes. It has been suggested that famesyl pyrophosphate (88) similarly serves as the carbon backbone of alkaloids such as deoxynupharidine (120) from JShtpharjaponicum (Nymphaceae) (water lilies) and dendrobine (121) from Dendrobium nobile Undl (Orchidaceae) (Table 11). [Pg.553]

Fig. 9. Piece of the upper epidermis of a petal of Dendrobium nobile plasmolyzed and treated with iodine in potassium iodide. The heavy shading indicates alkaloid precipitated in the cell vacuoles, surrounded by the protoplasm (lighter shading) containing the pigmented chromoplasts. After Wildeman (8).

Jiang, M., and S. Cheng. 1999. Dendrobium nobile juice. Shipin Kexue 20(11) 39-41. [Pg.311]

Miyazawa, M., H. Shimamura, S.-I. Nakamura, and H. Kameoka. 1997. Antimutagenic activity of gigantol from Dendrobium nobile. J. Agric. Food Chem. 45(8) 2849-2853. [Pg.311]

Dendrobium alkaloids. Alkaloids occurring in the orchid genus Dendrobium. Similar to the Nuphar alkaloids, these are pseudoalkaloids whose C-skeletons originate from terpene metabolism (sesquiterpenes). About 15 alkaloids are known, they were first isolated from Dendrobium nobile and later also from other species a typical representative is denr/w/nne C,6H25N02, Mr 263.38, mp. 134-136°C, [a]i -48.4° (CHjOH). ... [Pg.177]

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