Serum retinol binding protein

Sundaram, M., Sivaprasadarao, A., DeSousa, M.M. and Findlay, J.B.C. (1998) The transfer of retinol from serum retinol-binding protein to cellular retinolbinding protein is mediated by a membrane receptor. Journal of Biological Chemistry 273, 3336—3342. 

Chen, C.-C., and Heller, J. (1977). Uptake of retinol and retinoic acid from serum retinol-binding protein by retinal pigment epithelial cells. /. RieL Chem. 252,. 5216-. 5221. 

Fig. 2. Stereodiagrams of LBPs. The ribbon drawings of serum retinol-binding protein (a) and cellular retinol-binding protein (b) are shown in stereo. They are representative of the eLBP and iLBP families, respectively. The retinol molecule found bound to the crystalline protein is shown as a ball-and-stick model.

X. Members of eLBP Family with Known Crystal Structure A. Serum Retinol-Binding Protein... 

Serum retinol-binding protein (RBP) is a retinoid-binding protein found in the circulatory system. The protein is synthesized in the hepato-cytes, where it accumulates until the presence of its ligand in the circulation triggers the secretion of the complex (Ronne et cd., 1983 Good-... 

The overall folding of /3-LG is remarkably similar to that of human plasma retinol-binding protein (Papiz et al., 1986). The core is made up of an eight-stranded antiparallel /3 sheet, which forms a /3 barrel. There is also a short a helix at the C terminus. As described by Monaco et al. (1987), the interior of the /3 barrel is essentially hydrophobic. The conformational difference between the A form and B form of the protein is not significant. The most interesting observation is that the bound retinol molecule interacts with the protein in a way completely different from that of serum retinol-binding protein. The calculated difference map showed that the molecule is not located in the central j3 barrel but binds to the a-heIix//3-barrel interface delimited by about 15 residues. Most of the... 

Pervaiz S, Brew K. Homology and structure-function correlations between tti-acid glycoprotein and serum retinol-binding protein and its relatives. FASEB J 1987 1 209-14. 

Yang Q, Graham TE, Mody N, et ai. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005 436 356-362. 

Serum Retinol-Binding Protein, Obesity, and Insulin Resistance... 

Akbay, E., Muslu, N., Nayir, E. et al. 2010. Serum retinol binding protein 4 levels is related with renal functions in type 2 diabetes. J Endocrinol Invest 33 725—729. 

Aleman, G., Torres, N., and Tovar A, R. 2004. Peroxisome proliferator-activated receptors (PPARs) in obesity, and insulin resistance development Rev Invest Clin 56 351-367. An, C., Wang, H., Liu, X. et al. 2009. Serum retinol binding protein 4 is elevated and positively associated with insulin resistance in postmenopausal women. Endocr J 56 987-996. Balagopal, P., Graham, T. E., Kahn, B. B. et al. 2007. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention Association with subchnical inflammation. J Clin Endocrinol Metab 92 1971-1974. 

Cban, T. R, Tsai, Y. C., Wu, C. H. et al. 2011. Tbe positive correlation between cord serum retinol-binding protein 4 concentrations and fetal growth. Gynecol Obstet Invest 72 98-102. 

Cbang, Y. H., Lin, K. D., Wang, C. L. et al. 2008. Elevated serum retinol-binding protein 4 concentrations are associated with renal dysfunction and uric acid in type 2 diabetic patients. Diabetes Metab Res Rev 24 629-634. 

Graham, T. E., Wason, C. J., Bluher, M. et al. 2007. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia 50 814-823. 

Haider, D. G., Schindler, K., Prager, G. et al. 2007. Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects. J Clin Endocrinol Metab 92 1168-1171. 

Han, S. H., Chin, B. S., Lee, H. S. et al. 2009. Serum retinol-binding protein 4 correlates with obesity, insulin resistance, and dyslipidemia in HIV-infected subjects receiving highly active antiretroviral therapy. Metabolism 58 1523-1529. 

Jia, W., Wu, H., Bao, Y. et al. 2007. Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. J Clin Endocrinol Metab 92 3224-3229. 

Kim, I. K., Lee, H. J., Kang, J. H. et al. 2011. Relationship of serum retinol-binding protein 4 with weight status and lipid profile among Korean children and adults. Eur J Clin Nutr 65 226-233. 

Lee, J. W., Im, J. A., Lee, H. R. et al. 2007. Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women. Obesity 15 2225-2232. 

Mody, N., Graham, T. E., Tsuji, Y et al. 2008. Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice. Am J Physiol Metab 294 E785-E793. 

Su, Y. X., Hong, J., Yan, Q. et al. 2010. Increased serum retinol-binding protein-4 levels in pregnant women with and without gestational diabetes mellitus. Diabetes Metab 36 470-475. 

Suh, J. B., Kim, S. M., Cho, G. J. et al. 2010. Elevated serum retinol-binding protein 4 is associated with insulin resistance in older women. Metabolism 59 118-122. 

Muller, H N and Skerra, A. (1993) Functional expression of the uncomplexed serum retinol-binding protein m Escherichia coli J Mol Biol 230,725-732... 

Siegenthaler, G. (1990) Gel electrophoresis of cellular retinoic acid-binding protein, cellular retinol-binding protein, and serum retinol-binding protein. Meth. Enzymol 189, 299-307... 

Most of the retinol that is delivered to the eye originates in the liver, and is released into the circulation (mainly in the all-trans configuration) bound to an M, 21,000 protein, serum retinol-binding protein (RBP). This protein, which contains no bound lipid or carbohydrate, circulates as a 1 1 complex with transthyretin (TTR, originally prealbumin) (see Chapter 8 for detailed discussion). 

Shingleton JL, Skinner MK, Ong DE (1989) Characteristics of retinol accumulated from serum retinol-binding protein by cultured Sertoli cells. Biochemistry 28 9641-9647... 

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