Serum blood, components

A virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product or analogous product, or arsphenamine or its derivatives or any other trivalent organic arsenic compound applicable to the prevention, cure or treatment of disease or conditions of human beings... 

In the isolated perfused liver experiments, buffers containing no erythrocytes or serum proteins are used to examine the direct interaction of a gene drag with tissues and to avoid the interaction of a gene drag with blood components and possible contamination of nucleases. 

Biological samples (plasma, serum, blood, and urine) are very complex. They contain a wide variety of matrix components such as proteins, lipids, and salts. To quantify trace amount of analytes (e.g., drug and its metabolites) in complex biological samples by liquid chromatography-mass spectrometry (LC-MS), the samples should be properly treated prior to being injected onto an LC-MS instrument,... 

Nakamura et al. [42] developed a simple and rapid semi-micro colunm HPLC method with UV detection for the simultaneous determination of lornoxicam and other oxicams in human blood samples. The drugs including isoxicam as an internal standard were extracted from buffered plasma samples (pH 3) with dichloromethane and the resulting extracts were subjected to HPLC analysis. The separation was performed with a Ci8 reversed-phase semi-micro column (25 cm x 1.5 mm, 5 pm) at 35 °C. The mobile phase used was a mixture of acetonitrile-0.1 M acetate buffer (pH 5)-methanol, and the detection wavelength was set at 365 nm. The drugs were separated within 30 min without interference by the blood components. The detection limits of lornoxicam were 6.4 ng/ml in serum and 9.3 ng/ml in plasma at a signal-to-noise ratio of 3. The method was applied to the determination of lornoxicam in the sera of the patients. 

Fuji evolved their system on a multilayer film technique basis. The primary goal has always been the determination of components of the blood without requiring external separation of serum or plasma (i.e. a centrifuge). Hence, it was necessary to develop a layer that would retain the coarse corpuscular blood components (erythrocytes, leukocytes etc.). The principles of the construction of the slides and the method of measurement are in accordance with the instructions that have been given for the use of Kodak instruments (see p. Ektachem system). The instrument is not available in Europe or on the American continent. It has also not yet been presented at exhibitions or congresses. So far, only the slides (reagent carriers) for the measurement of glucose and urea have been described in detail (D1-D6). 

To verify that the content of the liposome does not leak when the formulation is exposed to blood components, the kinetics of HPTS release in serum can be monitored for different periods of time. 

Examples of combination products include drug-eluting stents, implantable insulin pumps, and skin patches that deliver protein therapies. A biological product is a virus, vaccine, therapeutic serum, toxin or antitoxin, blood, blood component or derivative, or allergenic that prevents, treats, or cures diseases or injuries to humans. Biological products include viral vaccines, human blood and plasma, and interferons and erythropoietins. 

The nutritional requirements of mammalian cells are more stringent than those of microorganisms since they do not metabolize inorganic nitrogen. Therefore, many amino acids and vitamins should be provided. Typical medium contains amino acids, vitamins, hormones, growth factors, mineral salts, and glucose. Furthermore, the medium needs to be supplemented with 2% to 20% (by volume) of mammalian blood serum. The serum provides components that have not yet been identified but are necessary for culture viability. 

The distinction between biopharmaceuticals under the jurisdiction of OBP and ONDG stems from the definition of a biological product in the PHS Act (42 USG 351 [262] (i)) a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, or analogous product, or arsphenamine or derivative of arsphenamine (or any other tri-valent organic arsenic compound), applicable to the prevention, treatment, or cure of a disease or condition of human beings. Biopharmaceuticals under the jurisdiction of OBP are analogous products under this definition. 

Callahan RJ, McKusick KA, Lamson III M, Castronovo FP, Potsaid MS (1976) Technetium-99m-hu-man serum albmnin Evaluation of a commercially produced kit. J Nucl Med 17 47-49 Council of Europe (1992) Guide for the preparation, use and quality assurance of blood components. Cormcil of Europe, Strasbourg... 

What are usually called liver function tests (LFTs) do not a.ssess quantitatively the capacity of that tissue to carry out any of the functions which are described above. T.FTs are measurements of blood components w hich simply provide a lead to the existence, the extent and the type of liver damage. Usually, a request for LFTs will provide results for bilirubin, the aminotransferases and alkaline phosphatase in a serum specimen. Know ledge of the serum albumin concentration may also be of some value in the investigation of liver disease. These biochemical investigations cun assist in differentiating the follow ing ... 

Exercise - even of short duration - causes changes in blood serum constituents, possibly due to leakage of intracellular components, e.g. enzymes from muscles. Continuous training may cause hemodilution this may in turn lead to apparently too low values of blood components. Changes caused by physical strain may even be seen in urinary excretion of trace elements, as exemplified by a 5-fold Increase of the urinary chromium excretion after running for 2 h (Anderson et al., 1982a). 

During pregnancy the plasma volume increases by a third this elicits changes in the concentrations of many blood components (Hytten and Leicht, 1971 Young, 1979) lac-tating may also affect serum composition, as exemplified by chromium (Anderson et al., 1993). 

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