Serotonin receptor localization

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Kohen, R., Metcalf, M. A., Khan, N. etal. (1996). Cloning, characterization and chromosomal localization of a human 5-HT6 serotonin receptor. /. Neurochem., 66, 47-56. 

Riad, M., Garcia, S Watkins, K. C. et al. (2000). Somatodendritic localization of 5-HTla and preterminal axonal localization of 5-HTlb serotonin receptors in adult rat brain. ]. Comp. Neurol. 417, 181-94. 

Many of these drugs have effects that are not mediated by Hi-receptors (Table 38.2). The antimuscarinic activity of several first-generation Hj-blockers may account for their effectiveness in combating motion sickness and their limited ability to suppress parkinsonian symptoms. The phenothiazines have some capacity to block a-adrenoceptors, whereas cyproheptadine Periactin) is an antagonist at serotonin receptors. Diphenhydramine Benadryl), pyrilamine (Ryna), and promethazine Phen-ergan) are effective local anesthetics. Many second-generation antihistamines also have been found to inhibit the non-histamine-mediated release of various... 

The first-generation H receptor antagonists have many actions in addition to blockade of the actions of histamine. The large number of these actions probably results from the similarity of the general structure (Figure 16-1) to the structure of drugs that have effects at muscarinic cholinoceptor, a adrenoceptor, serotonin, and local anesthetic receptor sites. Some of these actions are of therapeutic value and some are undesirable. 

Maroteaux L, Saudou F, Amlaiky N, Boschert U, Plassat JL, Hen R. Mouse 5HT1B serotonin receptor cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci USA 1992 89 3020-3024. 

Matthes H, Boschert U, Amlaiky N, et al. Mouse 5-hydroxytiyptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors cloning, functional expression, and chromosomal localization. Mol Pharmacol 1993 43 313-319. 

Ruat M, Traififort E, Leurs R, et al. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proc Natl Acad Sci USA 1993 90 8547-8551. 

Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System... 

Moyer RW, Kennaway DJ. Immunohistochemical localization of serotonin receptors in the rat suprachiasmatic nucleus. Neurosci Lett 1999 271 147-150. 

Hoyer D, Pazos A, Probst A, Palacios JM. Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain Res 1986 376 85-96. 

Cover illustration Figure 3 from Chapter 9, Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System, by L. Descarries, V. Comea-Hebert, and M. Riad... 

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