Serotonergic drug

Tollefson GD, Montague-Clouse J, Tollefson SL Treatment of comorbid generalized anxiety in a recently detoxified alcohol population with a selective serotonergic drug (buspirone). J Clin Psychopharmacol 12 19-26, 1992... 

Titeler. M. Lyon, R.A. Davis, K.A. and Glennon, R.A. Selectivity of serotonergic drugs for multiple brain serotonin receptors The role of H-DOB, a 5-HT2 agonist radioligand. Biochem Pharmacol 36 3265-3271,... 

Anticonvulsants, especially topiramate, and serotonergic drugs, especially ondansetron, show promise in initial, but well-designed, randomized controlled trials.43 Further studies are needed. Buspirone is well studied, but results are inconsistent. 

Trazodone, 25 to 100 mg, is often used for insomnia induced by selective serotonin reuptake inhibitors or bupropion. Side effects include serotonin syndrome (when used with other serotonergic drugs), oversedation, a-adrenergic blockade, dizziness, and rarely priapism. 

Whitaker, P. M., and Seeman, P. (1978) High-affinity 3H-serotonin binding to caudate Inhibition by hallucinogens and serotonergic drugs. Psychopharmacology, 59 1-5. 

Other serotonergic drugs that are direct receptor agonists or antagonists have been found to have anxiolytic effects (Stahl 1998 Bonhomme and Esposito 1998). A novel class of anxiolytic drugs called azapirones act as partial agonists at 5-HTlA receptors (Yocca 1990). Clinically, they are represented by BuSpar, which was approved for use in 1986 (Eison... 

Serotonin syndrome The serotonin syndrome is a rare complication of therapy with serotonergic drugs. When this problem occurs with SSRIs, it is most commonly in... 

Serotonergic drugs - antidepressants maprotUine, monoamine oxidase inhibitors, drug combinations with specific serotonin reuptake inhibitors causing the serotonin syndrome - lithium, LSD, MDMA... 

Serotonin syndrome is best prevented by not using serotonergic drugs in combination. Special care is needed when changing from an SSRI to an MAOI and vice versa. The SSRIs, particularly fluoxetine, have long half-lives and serotonin syndrome may occur if a sufficient wash-out period is not allowed before switching from one to the other. When changing... 

Murphy, D.L., Andrews, A.M., Wichems, C.H., Li, Q., Tohda, M., and Greenberg, B. (1998) Brain serotonin neurotransmission an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. J Clin Psychiatry 59 5uppl 15 4-12. 

DeBattista, C., Sofuoglu, M., and Schatzberg, A.F. (1998) Serotonergic synergism the risks and benefits of combining the selective serotonin reuptake inhibitors with other serotonergic drugs. Biol Psychiatry 44 341—347. 

The second major drug interaction involves combining MAOIs with serotonergic drugs, resulting in excessive... 

Serotonin syndrome (Sternbach, 1991) has been reported when St. John s wort is used concurrently with other serotonergic drugs. This syndrome is believed to be due to an excess stimulation of the 5-HTia receptor, probably as a result of the serotonergic activity of St. John s wort compounds. 

Some authors (Flament et ah, 1987) found that response to treatment with clomipramine was correlated with a marked decrease in platelet serotonin concentration and monoamine oxidase (MAO) activity. Changes in cerebrospinal fluid (CSF) neuropeptides and monoamine metabolites have also been described with chronic clomipramine administration (Swedo et ah, 1992 Altemus et ah, 1994). Despite these observations, the exact mechanism of action of serotonergic drugs (and the serotonin hypothesis ) remains unproven, although it is thought they mediate their effects via down-regulation of the presynaptic 5-HTlD autoreceptor (Rauch et ah, 1994). 

Catapano F, Monteleone P, Maj M, et al Dexamethasone suppression test and response to serotonergic drugs in OCD. European Psychiatry 6 273-274, 1991... 

The combination of bupropion with an M AOI is potentially dangerous, but less so than the combination of serotonergic drugs and MAOIs. Although the practice is not recommended, MAOIs and bupropion have been combined in patients with refractory depression. 

The combination of serotonergic drugs, such as SSRIs, with MAOIs can result in a potentially fatal hypermetabolic reaction, often... 

Discontinuation symptoms appear to occur most commonly after discontinuation of short-half-life serotonergic drugs (Coupland et al. 1996), such as fluvoxamine, paroxetine, and venlafaxine. 

Co-administration with other serotonergic drugs can result in development of the serotonin syndrome. In this, the patient is initially restless and may have nausea or diarrhoea. Hyperthermia, rigidity, tremor, myoclonus, autonomic instability, and convulsions may... 

Linezolid Prevents bacterial protein synthesis by binding to the 23S ribosomal RNA of 50S subunit Bacteriostatic activity against susceptible bacteria Infections caused by methicillin-resistant staphylococci and vancomycin-resistant enterococci Oral, IV hepatic clearance (half-life 6 h) dosed twice-daily Toxicity Duration-dependent bone marrow suppression, neuropathy, and optic neuritis serotonin-syndrome may occur when coadministered with other serotonergic drugs (eg, selective serotonin reuptake inhibitors)... 

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