Sepsis disseminated intravascular coagulation

Pathological findings frequently observed in organs of patients who have died of sepsis include disseminated intravascular coagulation (DIC), manifested as diffuse thrombotic occlusions in the entire microvascular system, associated with alterations in the hemostatic mechanism and clinical signs of hemorrhagic diathesis. Many observations indicate that DIC contributes to the major symptoms of the systemic inflammatory response syndrome (SIRS), which frequently complicate sepsis (HI, H2, H3, T6). 

Progression of uncontrolled sepsis leads to evidence of organ dysfunction, which may include oliguria, hemodynamic instability with hypotension or shock, lactic acidosis, hyperglycemia or hypoglycemia, possibly leukopenia, disseminated intravascular coagulation, thrombocytopenia, acute respiratory distress syndrome, GI hemorrhage, or coma. 

Plasma contains protease inhibitors that rapidly inactivate the coagulation proteins as they escape from the site of vessel injury. The most important proteins of this system are -anti protease, 2-macroglobulin, -antiplasmin, and antithrombin. If this system is overwhelmed, generalized intravascular clotting may occur. This process is called disseminated intravascular coagulation (DIC) and may follow massive tissue injury, cell lysis in malignant neoplastic disease, obstetric emergencies such as abruptio placentae, or bacterial sepsis. 

Deficiency of vitamin C due to a citrus-poor diet during pregnancy Hypervltaminosis A due to Ingestion of beef liver during pregnancy Deficiency of vitamin K because infant Intestines are sterile Deficiency of vitamin K because of disseminated Intravascular coagulation (disseminated clotting due to Infantile sepsis)... 

Viremia is common to many viral illnesses, but it does not usually lead to the development of chnical sepsis. Hypotension and disseminated intravascular coagulation (DIG) may occur with unusual viruses, such as Ebola virus and Lassa fever virus, and may be seen occasionally with influenza A, arbovirus, and possibly severe measles. ... 

Negative acute-phase reactant Sepsis, shock Disseminated intravascular coagulation Acute leukemia Acute pancreatitis Inherited deficit... 

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