Semicarbazide-sensitive amine oxidase SSAO

Semicarbazide-sensitive amine oxidase (SSAO) (rat) SSAO can generate vasoactive H2O2. HA (1 mM) inhibits staining of SSAO in rat aorta, and is thought to antagonize H202-induced vasoconstriction 26, 48... 

Amine oxidases catalyze the oxidative deamination of both xenobiotic and biogenic amines, and thus have many critical biological functions. Two distinct classes differ in the nature of their prosthetic groups [1]. The flavin-(FAD flavin adenine dinucleotide)-dependent amine oxidases include monoamine oxidases (MAO A and B) and polyamine oxidases. Amine oxidases not containing FAD, the so-called semicarbazide-sensitive amine oxidases (SSAO), include both plasma amine oxidases and tissue amine oxidases. These contain quinonoid structures as redox cofactors that are derived from posttranslationally modified tyrosine or tryptophan side chains, topaoquinone frequently playing this role [2]. 

Fig. 10.1 Cellular formation and metabolism of methylglyoxal (MG). AGEs advanced glycoxida-tion endproducts DHAP dihydroxyacetone phosphate G3P glyceraldehyde 3-phosphate F-6P fructose 6-phosphate F-1,6P2 fmctose 1,6-bisphosphate Gly-I II glyoxalase I II SSAO semicarbazide-sensitive amine oxidase AMO amine oxidase.

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