Self-emulsifying drug delivery

Araya H, Tomita M, Hayashi M (2006) The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion III The permeation mechanism of a poorly water soluble drug entrapped O/W microemulsion in rat isolated intestinal membrane by the Ussing chamber method. Drug Metab Pharmacokinet 21 45-53. 

Self-emulsifying drug delivery systems (SEDDS) are anhydrous solutions of the drug in oil containing surfactant and cosurfactant, which spontaneously emulsify when added to an excess of water. 

Charman, S.A., Charman, W.N., Rogge, M.C., Wilson. T.D., Dutko, F.J., and Pouton, C.W. (1992). Self-emulsifying drug delivery systems Formulation and biopharmaceutics evaluation of an investigational lipophilic compound. Pharm. Res., 9(1), 87-93. 

Pouton, C.W. (1985). Self-emulsifying drug delivery systems Assessment of the efficiency of emulsification. Int. J. Pharmaceutics, 27, 335-348. 

Pouton, C.W. (2000). Lipid formulations for oral administration of drugs Non-emulsifying and self-emulsifying drug delivery systems. Eur. J. Pharm. Sci., Suppl. 2, S93-S98. 

Kommuru, T.R., Gurley, B., Khan, M.A., Reddy, I.K. (2001). Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10 formulation development and bioavailability assessment. International Journal of Pharmaceutics, 212, 233-246. 

Pouton, C. W. 1997. Formulation of self-emulsifying drug delivery syst dsanced Drug Delivery Reviews 25 47-58. 

Self-emulsifying drug delivery systems are oral dosage forms consisting of drug, oils, surfactants, and sometimes cosolvents (Constantinides, 1995 Pouton, 1997 Pouton, 2000). On addition to water... 

Patil, P, J. Joshi, and P. Paradkar. 2004. Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery systems (SEDDS) of ketoprotetfPS Pharm Sci Te[Pg.527]

Self-Emulsifying Systems Emulsion systems have the disadvantage of being physically unstable, and over time a separation between the oil and water phases of the emulsion will occur. The use of conventional emulsions is also less attractive due to poor precision of the taken dose and the relatively large volume that has to be administered. To overcome these limitations, self-emulsifying drug delivery systems (SEDDS) have been developed. The... 

Currently, most mature dissolution controlled release systems/ technologies are applicable for water-soluble and low-water-solubility compounds (with low doses). For very poorly water-soluble compounds, dissolution controlled release systems/technologies may not be applicable because these compounds have intrinsically slow dissolution/release rates. Recently, several new technologies such as solid dispersions and self-emulsifying drug delivery systems (SEDDS) have been developed to deliver poorly water-soluble compounds at reasonable doses through enhancement of dissolution rate. These technologies have created new potentials for controlled release of poorly water-soluble compounds, often... 

N. H. Shah, M. T. Carvajal, C. I. Patel, M. H. Infeld, and A. W. Malick, Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs, Int. J. Pharmaceut. 106 15-23 (1994). 

B. Matuszewska, L. Hettrick, J. V. Bondi, and D. E. Storey, Comparative bioavailability of L-683,453, a 5a-reductase inhibitor, from a self emulsifying drug delivery system in beagle dogs, Int. J. Pharm. 736 147-154 (1996). 

Gursoy, R. N., and Benita, S. (2004), Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs, Biomed. Pharmacother. Dossier Drug Deliv. Drug Efficacy, 58,173-182. 

There are many different polyglycolyzed glycerides and they are generally used to formulate water-insoluble drugs in lipid based formulations such as self-emulsifying drug delivery systems (SEDDS) in order to improve oral... 

Microemulsions are thermodynamically stable isotropically clear dispersions composed of a polar solvent, oil, and a surfactant(s). Labrafil and Gelucire 44/14 are all-in-one self-emulsifying surfactants which are in many oral products throughout the world. Microemulsions have much potential for drug-delivery since very hydrophobic molecules can be solubilized and formulated for oral administration (Tenjarla, 1999). All of the commercial products are actually nonaqueous microemulsions, also known as microemulsion preconcentrates or self-emulsifying drug delivery systems (SEDDS), since the polar solvent is not water. Upon contact with aqueous media, such as gastrointestinal fluids, a SEDDS formulation spontaneously forms a fine dispersion or aqueous microemulsion. 

S. A. Charman, W. N. Charman, M. C. Rogge, T. D. Wilson, F. J. Dutko, and C. W. Pouton, Self-emulsifying drug delivery systems Formulation and biopharma-ceutical evaluation of an investigational lipophihc compound, Pharm. Res. 9 S7-93 (1992). 

Tipranavir is administered with a booster dose of ritonavir. The tipranavir/ritonavir must be taken with other anti-HIV drugs. Normal dosing consists of 500 mg of tipranavir and 200 mg of ritonavir twioe daily. Whereas tipranavir is a substrate for CYP3A4, in the presence of ritonavir very little metabolism of tipranavir occurs, although the combination leads to induction of P-glyooprotein, which may increase the bioavailability of tipranavir. By itself, tipranavir exhibits increased absorption in the presence of food. Initially, tipranavir was available as the disodium salt, but it was demonstrated that the free acid, in the form of a self-emulsifying drug delivery system (soft-gel capsules), showed improved bioavailability. 

---