Self emulsifying delivery system

Araya H, Tomita M, Hayashi M (2006) The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion III The permeation mechanism of a poorly water soluble drug entrapped O/W microemulsion in rat isolated intestinal membrane by the Ussing chamber method. Drug Metab Pharmacokinet 21 45-53. 

Self-emulsifying drug delivery systems (SEDDS) are anhydrous solutions of the drug in oil containing surfactant and cosurfactant, which spontaneously emulsify when added to an excess of water. 

Charman, S.A., Charman, W.N., Rogge, M.C., Wilson. T.D., Dutko, F.J., and Pouton, C.W. (1992). Self-emulsifying drug delivery systems Formulation and biopharmaceutics evaluation of an investigational lipophilic compound. Pharm. Res., 9(1), 87-93. 

Pouton, C.W. (1985). Self-emulsifying drug delivery systems Assessment of the efficiency of emulsification. Int. J. Pharmaceutics, 27, 335-348. 

Pouton, C.W. (2000). Lipid formulations for oral administration of drugs Non-emulsifying and self-emulsifying drug delivery systems. Eur. J. Pharm. Sci., Suppl. 2, S93-S98. 

Kommuru, T.R., Gurley, B., Khan, M.A., Reddy, I.K. (2001). Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10 formulation development and bioavailability assessment. International Journal of Pharmaceutics, 212, 233-246. 

Self-emulsifying drug delivery systems are oral dosage forms consisting of drug, oils, surfactants, and sometimes cosolvents (Constantinides, 1995 Pouton, 1997 Pouton, 2000). On addition to water... 

Patil, P, J. Joshi, and P. Paradkar. 2004. Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery systems (SEDDS) of ketoprotetfPS Pharm Sci Te[Pg.527]

Self-Emulsifying Systems Emulsion systems have the disadvantage of being physically unstable, and over time a separation between the oil and water phases of the emulsion will occur. The use of conventional emulsions is also less attractive due to poor precision of the taken dose and the relatively large volume that has to be administered. To overcome these limitations, self-emulsifying drug delivery systems (SEDDS) have been developed. The... 

Schwarz, J., Lee, M., Weisspapir, M., Zhang, Q., and Lu, W. Increased bioavailability of coenzyme Q-10 in self-emulsifying controlled release tablet New type of delivery system for hydrophobic drugs. Int. Symp. Contr. Rel. Bioact. Mater. 28 824—825, 2001. 

Currently, most mature dissolution controlled release systems/ technologies are applicable for water-soluble and low-water-solubility compounds (with low doses). For very poorly water-soluble compounds, dissolution controlled release systems/technologies may not be applicable because these compounds have intrinsically slow dissolution/release rates. Recently, several new technologies such as solid dispersions and self-emulsifying drug delivery systems (SEDDS) have been developed to deliver poorly water-soluble compounds at reasonable doses through enhancement of dissolution rate. These technologies have created new potentials for controlled release of poorly water-soluble compounds, often... 

In this chapter we will provide a brief overview of the early approaches to bioavailability enhancement by use of simple lipid-based delivery systems (lipid solutions, emulsions etc), and then describe recent progress in the application of self-emulsifying- and microemulsion-based formulations. The effects of lipids on the oral bioavailability of co-administered poorly water-soluble drugs may also be classified from a mechanistic (and to a degree, historical) perspective as physicochemically mediated effects (solubility, dissolution, surface area) and biochemically mediated effects (metabolism, transport related events), and these will be approached separately. It is readily apparent, however, that in many cases physicochemically and biochemically mediated mechanisms will operate side by side. In some instances, bioavailability may also be enhanced by the stimulation of intestinal lymphatic transport, and these studies will be addressed in a separate section. 

N. H. Shah, M. T. Carvajal, C. I. Patel, M. H. Infeld, and A. W. Malick, Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs, Int. J. Pharmaceut. 106 15-23 (1994). 

B. Matuszewska, L. Hettrick, J. V. Bondi, and D. E. Storey, Comparative bioavailability of L-683,453, a 5a-reductase inhibitor, from a self emulsifying drug delivery system in beagle dogs, Int. J. Pharm. 736 147-154 (1996). 

Pouton, C. W. (1997), Formulation of self-emulsifying drug delivery systems for peptides reduced plasma testosterone levels in male rats after a single injection, Int. J. Pharm., 25,47-58. 

It has been shown in a number of studies that the incorporation of drug in o/w nanosized emulsions significantly increased the absorption of the drug when compared with the equivalent aqueous solution administered orally [132-135], However, the use of emulsions for oral application is limited since other attractive alternatives, such as self-emulsifying oil delivery systems, which are much less sensitive and easy to manufacture, are available [136,137], Thus the potential of nanosized emulsions after administration with parenteral and traditional nonparenteral topical routes such as ocular, percutaneous, and nasal is covered in this section. 

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