Self micro-emulsifying delivery system

This principle of anhydrous concentrates was named SMEDDS , self micro-emulsifying dmg delivery systems. Such formulations lack the aqueous phase. On dilution, a SMEDDS spontaneously converts to an optically clear, thermodynamically stable microemulsion, which contains the dmg in molecular dispersion. The same principle of a water-free concentrate which leads to a macro -emulsion is called SEDDS, a self-emulsifying dmg delivery system. A recent review on self-dispersing lipid based systems was... 

Kyatanwar AU, Jadhav KR, and Kadam VJ. (2010). Self micro-emulsifying drug delivery system (SMEDDS) Review. Journal of Pharmacy Research, 3, 75-83. 

Patel, P.V., et al., 2013. Self micro-emulsifying drug delivery system of tacrolimus formulation, in vitro evaluation and stabihty studies. InL J. Pharm. Invest. 3 (2), 95-104. http //www. pubmedcentral.nih.gov/articlerender.fcgi artid=3757905 tool=pmcentrez rendertype= abstract (accessed 18.02.15.). 

Rahman, M.A., 2013. Role of excipients in successfid development of self-emulsilying/micro-emulsifying drug delivery system (SEDDS/SMEDDS). Drug Dev. Ind. Pharm. 39, 1-19. http //www.ncbi.nlm.nih.gov/pubmed/22372916 (accessed 14.10.15.). 

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