Seizures organophosphate-induced

Harrison, P.K., Sheridan, R.D., Green, A.C., Scott, I.R., Tattersall, J.E. (2004). A guinea pig hippocampal slice model of organophosphate-induced seizure activity. J. Pharmacol. Exp. Ther. 310 678-86. 

Samson FE, Pazdernik TL, Cross RS et al. (1985). Brain regional activity and damage associated with organophosphate induced seizures effects of atropine and benactyzine. Proc West Pharmacol Soc, 28, 183-185. 

Neurological Headache, coma, loss of reflexes, Cheyne-Stokes respiration, seizures, electroencephalogram abnormalities Organophosphate-induced delayed polyneuropathy manifested by flaccidity or paralysis of extremities, paresthesias, footdrop, gait ataxia, spasticity develops 1-2 weeks after exposure Intermediate syndrome 1-4 days after exposure manifested by weakness of proximal limb and respirator muscles, loss of knee reflexes, cranial nerve palsy, death... 

Drewes, L.R., Singh, A.K., 1985. Transport, metabolism and blood flow in brain during organophosphate induced seizures. Proc. West. Pharmacol. Soc. 28, 191-195. 

Myhrer, T., Aas, P., 2010. Dissecting neurochemical mechanisms of nerve agent-induced seizures in search for target areas for medical countermeasures. In Weissman, B.A., Raveh, L. (Eds.), The Neurochemical Consequences of Organophosphate Poisoning in the CNS Transworld Research Network, Trivandrum, India, pp. 41-60. 

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