Organophosphate-induced delayed polyneuropathy

Lotti, M. (1986) Biological monitoring for organophosphate-induced delayed polyneuropathy, Toxicology Letters, 33 167-172. 

Lotti, M. (1987) Organophosphate-induced delayed polyneuropathy in humans perspectives for biomonitoring, Trends in Pharmacological Sciences, 8 176-177. 

Lotti M, Moretto A Organophosphate-induced delayed polyneuropathy. Toxicol Rev 2005 24 37. [PMID 16042503]... 

Lotti, M., Moretto, A. (2005). Organophosphate-induced delayed polyneuropathy. Toxicol. Rev. 24 37-49. 

Lotti, M., Moretto, A., Zoppellari, R., Dainese, R., Rizzuto, N., Barusco, G. (1986). Inhibition of lymphocytic neuropathy target esterase predicts the development of organophosphate-induced delayed polyneuropathy. Arch. Toxicol. 59 176-9. 

Lotti M (2002) Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors. Toxicology 181-182 245-248. 

Organophosphorus compounds (OPC) cause two major toxic effects. The first is the well-known acute toxicity initiated by inhibition of acetylcholinesterase (AChE) with subsequent accumulation of acetylcholine at nerve endings. The second effect is organophosphate-induced delayed polyneuropathy (OPIDP) (ataxia and paralysis appearing 2-3 weeks after exposure) associated with inhibi-... 

Physiological substrate for CarbE is probably O-acetyl sialic acid [57], CarbE can be differentiated from other serine esterases AChE (EC 3.1.1.7) and ChE (EC 3.1.1.8) in that AChE and ChE react with positively charged esters such as acetylcholine and butyrylcholine and can be inhibited with carbamates, while CarbE do not react with positively charged esters and inhibition with carbamates occurs only at high concentrations. Inhibition of CarbE, except inhibition of neuropathy target esterase associated with organophosphate-induced delayed polyneuropathy, does not cause any known toxic effects. 

Moretto, A., Capodicasa, E., and Lotti, M., Clinical expression of organophosphate-induced delayed polyneuropathy in rats, Toxicol. Lett., 63( 1), 97-102,1992. 

Johnson, M.K., Receptor or enzyme The puzzle of NTE and organophosphate induced delayed polyneuropathy, Trends Pharmacol. Sci.,8,174-179,1987. 

Jokanovic, M, Stepanovic-Petrovic, R.M., Maksimovic, M., Jovanovic, D., Kosanovic, M., Piperski, V., Effects of atropine, trimedoxime and methy lprednisolone on the development of organophosphate-induced delayed polyneuropathy in the hen. Exp Toxicol Pathol. 53(2-3), 129-132, 2001. 

Separate from the acute effects of anticholinesterases upon the neuromuscular junction (discussed previously), two further syndromes involving the neuromuscular system have been associated with OP poisoning. These are (1) the intermediate syndrome (IMS), and (2) organophosphate-induced delayed polyneuropathy (OPIDP). 

Neurological Headache, coma, loss of reflexes, Cheyne-Stokes respiration, seizures, electroencephalogram abnormalities Organophosphate-induced delayed polyneuropathy manifested by flaccidity or paralysis of extremities, paresthesias, footdrop, gait ataxia, spasticity develops 1-2 weeks after exposure Intermediate syndrome 1-4 days after exposure manifested by weakness of proximal limb and respirator muscles, loss of knee reflexes, cranial nerve palsy, death... 

Organophosphate-induced delayed polyneuropathy manifested by flaccidity or paralysis of extremities, paresthesias, footdrop, gait ataxia, spasticity develops 1-2 weeks after expo-... 

Jokanovic, M., P. V. Stukalov, and M. Kosanovic. 2002. Organophosphate induced delayed polyneuropathy. Current Drug Targets and CNS Neurological Disorders 1 593-602. 

Various organophosphates induce delayed polyneuropathy (OPIDP), which is characterized by sensations in limbs, weakness and even paralysis. Neuropathy target... 

Sun, D. H Zhou, H, D., and Xue, S. Z, (1998), Epidemiologic. survey on organophosphate-induced delayed polyneuropathy (OPIDP) among patients recovered from methamidophos poisoning. Med. Lav. 89(Suppl. 2), S 123-S125. 

X. PREVENTION AND TREATMENT OF ORGANOPHOSPHATE-INDUCED DELAYED POLYNEUROPATHY... 

Jokanovic, M., Kosanovic, M., Brkid, D., et al, 2011. Organophosphate induced delayed polyneuropathy in man an overview. Clin. Neurol. Neurosurg. 113,... 

A number of syndromes have been associated with OP exposure, and these are listed in Table 10.3. Some of these syndromes, notably the acute cholinergic syndrome, are largely caused by acetylcholine aeeumulation, whereas another, organophosphate-induced delayed polyneuropathy (OPIDP), clearly is not. 

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