Seizures cocaine-induced

Cerebrovascular vasoconstriction and a sudden increase in blood pressure probably underlie the many reports of cocaine-induced strokes, CNS hemorrhage, and migraine (SEDA-17, 1). Three cases of generalized seizures occurring shortly after the intravenous use of cocaine (143). 

Lathers CM, Tyau LS, Spino MM, Agarwal I. Cocaine-induced seizures, arrhythmias and sudden death. J Clin Pharmacol 1988 28(7) 584-93. 

Crack Cocaine Street Names Freebase. Mexican speedballs (crack w/ methamphetamine), roosten tornado (ovct 40 street slang terms) Use Crack is cocaine that comes in a rock crystal that can be heated and its vapors smoked. The tOTn crack ref s to the crackling sound heard when it is heated Actions CNS stimulant induces euphoria. Highly addictive Effects Acute CV or cerebrovascular emergencies (heart attack or stroke), could result in sudden death. Cocaine-related deaths are often a result of cardiac arrest or seizure followed by resp arrest (see also Cocaine)... 

At higher doses, cocaine can produce undesirable effects, including tremor, emotional lability, restlessness, irritability, paranoia, panic, and repetitive stereotyped behavior. At even higher doses, it can induce intense anxiety, paranoia, and hallucinations, along with hypertension, tachycardia, ventricular irritability, hyperthermia, and respiratory depression. In overdose, cocaine can cause acute heart failure, stroke, and seizures. Acute intoxication with cocaine produces these various clinical effects, depending on the dose these effects are mediated by inhibition of the dopamine transporter and in turn by the effects of excessive dopamine activity in dopamine synapses, as well as by norepinephrine and serotonin in their respective synapses. 

Of 279 patients who presented to a hospital emergency service between 1994 and 1998 with a first tonic-clonic seizure, 17 (6.1%) had seizures that were thought to be drug-related (5). The most common drug-induced causes were cocaine intoxication (6/17) and benzodiazepine withdrawal (5/17) followed by amfebutamone use (4/17). While one amfebutamone-associated seizure occurred in a 26-year-old woman without any other risk factors, the... 

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