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Mucosal addressin cell adhesion

During the generation of functional lymphoid tissue organizers, LT-pR signaling leads to expression of mucosal addressin cell adhesion molecule (MAdCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular cell-adhesion molecule 1 (VCAM-1) on endothelial cells, as well as the production of the chemokines CXCL13, CCL19, and CCL21 by stromal cells and HEVs (Carlsen et al., 2005). [Pg.143]

Wright N., Hidalgo A., Rodriguez-Frade J. M., et al. (2002) The chemokinestromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin. J Immunol., 168, 5268-77. [Pg.40]

Figure 1 Movement of T lymphocytes from the blood into the lymph nodes, (a) Soluble or endothelial-displayed CCL21 ( ) binds CCR7 ( ). (b) The interaction induces a change in the conformation of the integrin tt4P7 from low affinity (I) to high affinity ( ). (c) The high affinity integrin then binds to mucosal addressin cell adhesion molecule-1, MAdCAM-1 (C), causing cell adhesion, (d) Directed cell migration between endothelial cells results. Figure 1 Movement of T lymphocytes from the blood into the lymph nodes, (a) Soluble or endothelial-displayed CCL21 ( ) binds CCR7 ( ). (b) The interaction induces a change in the conformation of the integrin tt4P7 from low affinity (I) to high affinity ( ). (c) The high affinity integrin then binds to mucosal addressin cell adhesion molecule-1, MAdCAM-1 (C), causing cell adhesion, (d) Directed cell migration between endothelial cells results.
Pachynski RK, Wu SW, Gunn MD, Erie DJ. Secondary lymphoid-tissue cytokine stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. J Immunol 1998 161 953-956. [Pg.60]

MAdCAM Mucosal addressin cell adhesion molecule... [Pg.92]

P7 a4 Fibronectin, VCAM, Mucosal addressin cell adhesion molecule (MAdCAM)... [Pg.98]

See other pages where Mucosal addressin cell adhesion is mentioned: [Pg.12]    [Pg.136]    [Pg.59]    [Pg.43]    [Pg.4]    [Pg.249]    [Pg.43]    [Pg.50]    [Pg.1718]    [Pg.12]    [Pg.136]    [Pg.59]    [Pg.43]    [Pg.4]    [Pg.249]    [Pg.43]    [Pg.50]    [Pg.1718]    [Pg.209]    [Pg.145]    [Pg.145]    [Pg.24]   


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Cell adhesion

Cell adhesive

Mucosal

Mucosal addressin cell adhesion molecule-1 (MAdCAM

Mucosal cells

Mucositis

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