Secobarbital interaction

Compared to the benzodiazepine sedative-hypnotics, secobarbital is more lethal in overdosage, has a higher tendency for abuse and addiction, and is more likely to cause drug interactions via induction of hepatic microsomal enzymes few advan-fages if any in safety or efficacy over benzodiazepines... 

R. A. O Reilly, W, E Trager, C. H. Motley, and W. Howald, Interaction of secobarbital with warfarin pseudoracemates, Clin. Pharmacol. Then, 28 187 (1980). 

Clinically important, potentially hazardous interactions with aprobarbital, butabarbital, chloral hydrate, ethchlorvynol, mephobarbital, pentobarbital, phenobarbital, phenothiazines, primidone, secobarbital, zolpidem... 

Clinically important, potentially hazardous interactions with alcohol, anticholinergics, barbiturates, benzodiazepines, butabarbital, chloral hydrate, chlordiazepoxide, chlorpromazine, clonazepam, clorazepate, diazepam, ethchlorvynol, fluphenazine, flurazepam, hypnotics, lorazepam, MAO inhibitors, mephobarbital, mesoridazine, midazolam, narcotics, oxazepam, pentobarbital, phenobarbital, phenothiazines, phenylbutazone, primidone, prochlorperazine, promethazine, quazepam, secobarbital, sedatives, temazepam, thioridazine, tranquilizers, trifluoperazine, zolpidem... 

Clinically important, potentially hazardous interactions with allopurinol, amiodarone, amobarbital, anabolic steroids, anti-thyroid agents, aprobarbital, aspirin, barbiturates, bivalirudin, butabarbital, butalbital, cimetidine, clofibrate, clopidogrel, cyclosporine, delavirdine, disulfiram, fenofibrate, fluconazole, gemfibrozil, glutethimide, imatinib, itraconazole, ketoconazole, levothyroxine, liothyronine, mephobarbital, methimazole, metronidazole, miconazole, penicillins, pentobarbital, phenobarbital, phenylbutazones, piperacillin, prednisone, primidone, propylthiouracil, quinidine, quinine, rifabutin, rifampin, rifapentine, rofecoxib, salicylates, secobarbital, sulfinpyrazone, sulfonamides, testosterone, thyroid, zileuton... 

Clinically important, potentially hazardous interactions with amlodipine, anisindione, anticoagulants, aprepitant, atorvastatin, barbiturates, benzodiazepines, butabarbital, carbamazepine, chlordiazepoxide, clarithromycin, clonazepam, dorazepate, corticosteroids, cyclosporine, dexamethasone, diazepam, dicumarol, erythromycin, ethotoin, felodipine, flurazepam, fluvastatin, fosphenytoin, isradipine, itraconazole, ketoconazole, lorazepam, lovastatin, mephenytoin, mephobarbital, midazolam, nicardipine, nifedipine, nimodipine, nisoldipine, oxazepam, pentobarbital, phenobarbital, pimozide, pravastatin, primidone, quazepam, rifampin, secobarbital, simvastatin, St John s wort, temazepam, warfarin... 

Phenobarbital has been shown to decrease serum carbamazepine half-life and plasma concentration levels when given in combination. Significant changes in carbamazepine serum concentrations were seen within 5 days after the addition of phenobarbital to the therapeutic regimen. Conversely, carbamazepine appears to have no effect on serum phenobarbital levels. It has been reported to lower serum concentrations of primidone, but the decrease does not appear to be clinically significant. Other barbiturates (e.g., amobarbital, butabarbital, secobarbital) may interact in a manner similar to phenobarbital because of pharmacologic similarity. 

Churchill D, Yacoub JM, Siu KP, Symes A, Gault MH. Toxdc nephropathy after low-dose methoxyfhnane anesthesia drug interaction with secobarbital Can Med Assoc J (1976) 114,... 

Bellville JW, Forrest WH, ShrofFP, BrownBW. The hypnotic effects of codeine and secobarbital and their interaction in man. ChnPharmacol T7ter(l97V) 12,607-12. 

O Reilly RA, Trager WF, Motley CH, Howald W. Interaction of secobarbital witii warfarin pseudoracemates. Clin Pharmacol Ther 9Z0) 28,187-95. 

Srinivasan, K. Zhang, W. Bartlett, M.G. Rapid simultaneous capillary electrophoretic determination of (R)- and (S)-secobarbital from serum and prediction of hydroxypro-pyl-y-cyclodextrin—secobarbital stereoselective interaction using molecular mechanics simulation. J. Chromatogr. Sci. 1998, 36, 85-90. 

Cannabis has been reported to interact with physostigmine to produce severe depression (3 ). In a recent randomized trial, THC in a dose of 25 /rg given over a 50-minute period had an effect on various psychomotor effects which was additive with that of an effective dose of secobarbital (23 ). 

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