Secobarbital

Allyl 5 (1 methylbutyl) barbitunc acid (secobarbital Seconal)... 

Although most anesthetics are achiral or are adininistered as racemic mixture, the anesthetic actions are stereoselective. This property can define a specific, rather than a nonspecific, site of action. Stereoselectivity is observed for such barbiturates as thiopental, pentobarbital, and secobarbital. The (3)-enantiomer is modestly more potent (56,57). Additionally, the volatile anesthetic isoflurane also shows stereoselectivity. The (3)-enantiomer is the more active (58). Further evidence that proteins might serve as appropriate targets for general anesthetics come from observations that anesthetics inhibit the activity of the enzyme luciferase. The potencies parallel the anesthetic activities closely (59,60). 

Figure 11.19 SPME-CE analysis of urine samples (a) blank urine (a) directly injected and extracted for (b) 5 (c) 10 and (d) 30 min (b) Urine spiked with barbiturates, extracted for (e) 30 and (f, g) 5 min. Peak identification is as follows 1, pentobaitibal 2, butabarbital 3, secobarbital 4, amobarbital 5, aprobarbital 6, mephobarbital 7, butalbital 8, thiopental. Concenti ations used are 0.15-1.0 ppm (e, f) and 0.05-0.3 ppm (g). Reprinted from Analytical Chemistry, 69, S. Li and S. G. Weber, Determination of barbiturates by solid-phase microexti action and capillary electrophoresis, pp. 1217-1222, copyright 1997, with permission from the American Chemical Society.

Prajmaline bitartrate Secobarbital sodium T rioxsalen Allyl carbamide Meralluride... 

Short-acting (eg, secobarbital [Seconal], pentobarbital [Nembutal]). The average duration of action of the short-acting barbiturates is 3 to 4 hours. 

C]7H24N20, 2378-95-2) see Methotrexate diethyl Ai-(5-methylamino-2-thenoyl)-L-glutamate (C15H22N2O5S 112889-02-8) see Raltitrexed diethyl (l-methylbutyl)malonate (C12H22O4 117-47-5) see Secobarbital diethyl methylmalonate... 

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