Scutellaria baicalensis flavonoids from

Zhang, Y.-Y. et al., Four flavonoids from Scutellaria baicalensis. Phytochemistry, 35, 511, 1994. 

Separation, purification and identification have yielded baicalein, baicalin and other Free-B-Ring flavonoids as the major active components in the organic extract from the roots of Scutellaria baicalensis, and S. orthocalyx. In Table 2, we demonstrated the potencies of five Free-B-Ring flavonoids isolated from three different Scutellaria species. 

Based on Free-B-Ring flavonoids from the roots of Scutellaria baicalensis and flavans from the bark exudates of Acacia catechu, a novel... 

HIROTANI, M., KURODA, R., SUZUKI, H., YOSHIKAWA, T., Cloning and expression of UDP-glucose flavonoid 7-O-glucosyltransferase from hairy root cultures of Scutellaria baicalensis. Planta, 2000,210, 1006-1013. 

Since ancient times, the roots of Scutellaria baicalensis have been used to treat allergic and inflammatory diseases in China and Japan. We reported the isolation from these roots of three new compounds, i.e., 2 S), 2, 5,6, 7-tetetahydroxy flavanone[25], 2 R), 3(i )-2, 3,5,6, 7-pentahydroxyflavanone and 2, 5,5, 7-tetrahydroxy-6, 8-dimethoxy-flavone, as antibacterial or anti-lipid peroxidation substances [26, 27], as well as six flavonoids, i.e., baicalein, bailcalin, oroxylin A, wogonin, skullcapflavone II, etc. Furthermore, we found that baicalein and baicalin "Fig. (47)" suppressed the development of secondary lesions in adjuvant-induced arthritis in rats "Fig. (48)". 

Flavonoids such as baicalein from Scutellaria baicalensis and S. lateriflora inhibit pro-inflammatory metabolites including certain prostaglandins and leukotrienes. Quercetin and others are effective inhibitors of the release of histamine induced by various agents. They inhibit a number of stages of inflammation including granulation tissue formation in chronic arthritis (Middleton and Drzewiecki... 

Butenko IG, Gladtchenko SV, Galushko SV (1993) Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baiealein from Scutellaria baicalensis Georgy roots. Agents Actions 39 C49-C51... 

Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi Biochim Biophys Acta 1999 1472 643-650. 

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