Skin bruising

Physical examination of the musculoskeletal system (e.g., biceps, triceps, quadriceps, temporalis, deltoid, and interosseus muscles) for loss of muscle mass, and examination of the skin and mucous membranes for abnormalities (e.g., noting dry or flaky skin, bruising, edema, ascites, poorly healing wounds) and loss of subcutaneous fat... 

Side effects of inhaled corticosteroids are relatively mild and include hoarseness, sore throat, oral candidiasis, and skin bruising. Severe side effects such as adrenal suppression, osteoporosis, and cataract formation are reported less frequently than with systemic corticosteroids, but clinicians should monitor patients receiving high-dose chronic inhaled therapy. 

Cartier A, Malo JL. Skin bruising in asthmatic subjects treated with high doses of inhaled steroids frequency and association with adrenal function. Eur Respir J 1996 9(2) 226-31. 

Malo JL, Cartier A, Ghezzo H, Mark S, Brown J, Laviolette M, Boulet LP. Skin bruising, adrenal function and markers of bone metabolism in asthmatics using inhaled beclomethasone and fluticasone. Eur Respir J 1999 13(5) 993-8. 

The liver is the principal metabolic organ, and hepatic disease or dysfunction may impair drug elimination. Any alteration in the serum albumin or bilirubin levels and in the prothrombin time indicates impaired liver function. Similarly, skin bruising and bleeding tendency indicate decreased production of clotting factors by the liver. 

I remembered that when he had called in the early morning, my hair had been round my shoulders and my skin bruised with Aislabie s kisses. Is that what he meant How much freedom did your wife have I demanded. His eyes went blank and he looked over my head, but he had maddened me with his self-righteous preaching, so I persisted Well Did your wife rejoice in perfect equality Did her voice matter as much as yours ... 

MITOMYCIN HORMONES AND HORMONE ANTAGONISTS -TAMOXIFEN t incidence of anaemia and thrombocytopenia and risk of haemolytic-uraemic syndrome Mitomycin causes subdinical endothelial damage in addition to the thrombotic effect on platelets caused by tamoxifen, which leads to haemolytic-uraemic syndrome Monitor renal function at least twice weekly during concurrent therapy and watch clinically for bleeding episodes, e.g. nose bleeds, bleeding from the gums, skin bruising... 

Vitamin C supplemertts improve wound-healing and decrease skin-bruising in some types of Ehlers-Danlos syndrome... 

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