Screening strategies

An NMR screening strategy in which a small but diverse set of small molecules is screened against a potential drug target was recently described... 

Fig. I The desired attributes of a lead molecule. Often, molecules identified by any screening strategy might satisfy optimal criteria for only a subset of these attributes and most laboratories would proceed with a medicinal chemistry campaign banking on improving the rest in a subsequent lead optimization phase...

Because CKD often presents without symptoms, assessment for CKD relies on appropriate screening strategies in all... 

Outline preventive and screening strategies for individuals at average and high risk for colon cancer. 

Oberdorster, G. et al. (2005) Principles for characterizing the potential human health effects from exposure to nanomaterials elements of a screening strategy. Particle and Fibre Toxicology, 2 (1), 8. 

The Use of a Concerted RT-PCR mRNA Differential Display Screening Strategy 401... 

The screening strategy for systematic toxicological analysis (STA) must be very extensive, because several thousands of drugs or pesticides should be considered. In STA the substance(s) present is (are) not known at the start of the analysis. In such a... 

ICEMC (1983). Committee Final Report screening strategy for chemicals that are potential germ-cell mutagens in mammals. Mutation Res. 114 117-177. 

This review focuses upon NMR screening strategies and discusses how compound libraries can be designed to provide information pertinent to the specific strategy being pursued. The principles and tools of library construction are described and illustrated by the example of the approach used in our laboratory. The technical details of experimental methods will not be discussed here since they are reviewed in other chapters of this volume and elsewhere [1],... 

These selectivity differences provide a rational basis for a three-column initial screening strategy a strongly hydrophobic column, a weakly hydrophobic column, and a phenyl column. Commercially available columns are not indexed in a manner that easily allows column selection based on hydrophobicity however, butyl columns are good candidates for strongly hydrophobic columns. Columns with names like ether-, iso-, and isopropyl are good candidates for weakly hydrophobic columns. 

Using a microbial screening strategy, Shafiee et al. found that the chiral hydroxyester... 

A. Rapid Screening Strategies in Normal- and Reversed-Phase Liquid Chromatography... 

Another screening strategy using the same type of columns but with normal-phase gradient elution has been proposed by the pharmaceutical group Lilly.In this strategy, each compound is screened on four columns, i.e., Chiralcel OD-H, Chiralpak AD, Chiralpak AS and Chiralcel OJ. An n-hexane/2-propanol and an n-hexane/EtOH gradient elution system are... 

Very recently, the pharmaceutical group Astra-Zeneca proposed a screening strategy involving the use of both polysaccharide and macrocyclic glycopeptide columns. It is proposed to screen the compounds on seven different columns Chiralcel OD-H, Chiralpak AD, Chiralpak AS, Chiralcel... 

---