Molecular screening strategies

Can Molecular Screening Strategies Be Useful In The Search For Natural Products ... 

On the other hand, we have been very successful in evolving a new enzyme as an industrial enzyme. The technology requires exactly the same strategy as in the screening for new enzymes, although some wider fluctuation of the fidelity of PCR or related molecular screening should be necessary. 

One approach to screening subsets of available compounds is to screen sets of compounds that, although not representative of the molecular diversity of the available compound collection, do contain as much structure activity relationship information as possible. An example of this was the Informer Library strategy proposed by CombiChem (which was eventually purchased by DuPont Pharmaceuticals in 1999) (23). Unfortunately, there have been no published applications of this screening strategy that assess its success or failure. 

Harvey PW, Everett DJ (2003) The adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity critical omissions from regulatory endocrine disrupter screening strategies for human health J Appl Toxicol 23(2) 81-87... 

In many cases, the focus of new research has shifted to synthetic non-peptidic molecules of low molecular weight. Towards this end, we at Parke-Davis initiated a screening strategy to identify a nonpeptide hit suitable for further optimization. The implementation of this strategy and the optimization of the resulting lead are the focus of this review article. 

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