Screening reactors

Muller, A., Drese, K., Gnaser, H., Hampe, M., Hessel, V, Lowe, H., Schmitt, S., Zapf, R., A combinatorial approach to the design of a screening reactor for parallel gas phase catalyst screening, Chim. Oggi 21, 9 (2003)... 

Figure 11.23 Comparison of a 384-parallel single-bead reactor and a 48-parallel secondary screening reactor for a set of reference catalysts in a partial oxidation reaction.

Since the development of Stage II-screening reactor systems in 1998 [71], the 48-fold reactor technology is, in the meantime, a state-of-the-art methodology in the context of robustness, cost, and efficiency, and operates 24 h a day, 7 days a week, which is eased by the use of a smart control... 

Figure 11.26 Plot of the position sensitivity of the degree of conversion for a set of 48 bismuth-molybdate catalysts (same batch) in propylene to acrolein conversion in a Stage II 48-fold-screening reactor (reaction conditions 2% hydrocarbon in air at GHSV of 3000 h-1, column no. 8 contains only inert carrier material).

Buchmeiser, M.R., Lubbad, S., Mayr, M. and Wurst, K., Access to silica- and monolithic polymer supported C-C-coupling catalysts via ROMP applications in high-throughput screening, reactor technology and biphasic catalysis, Inorg. Chim. Acta, 2003, 345, 145. 

Finding this regular pattern of product distribution in accordance with the validation library (Figs. 2.6 and 2.7) manifests the two main features of the screening reactor set-up (1) In accordance with the XRF analysis, the sample synthesis fulfils all the requirements of a high-throughput synthesis method. Materials synthesized under the same conditions show very similar, not to say identical, results in the validation reaction. (2) Reaction conditions such as fluid and temperature distribution are the same for all 96 reactor positions. The same materials produce... 

Fig. 3.6 Schematic of the microfluidic parallel screening reactor system showing (a) reaction station, (b) spray station, and (c) imaging station.

Fig. 3.8 Schematic of the Microfluidic Parallel Screening Reactor System showing a single reaction/detection channel.

Acrylonitrile is commercially produced from propylene by a molybdate-based catalyst that has been optimized to produce a yield of around 80% acrylonitrile. Utilizing a less-expensive feedstock, the selective ammoxidation of propane to acrylonitrile has significant potential in reducing acrylonitrile production cost. The work-flow for this chemistry consisted of a primary scale evaporative synthesis station and 256-channel parallel screening reactor using a proprietary optical-based detection method. For the initial work shown here, secondary screening was done on a six-channel fixed-bed reactor. 

The reaction is also influenced by the heat of reaction developing during the conversion of the reactants, which is a problem in tubular screening reactors. In microstructures, the heat transport through the walls of the channels is facilitated by their small dimensions, which allows the development of isothermal reaction conditions. Thus, by decoupling the heat and mass balance, an analytical description of the flow in the screening reactor is achievable. 

Fig.4.5 Screening reactor at IMM with catalysts in separate drawers (gas distribution section removed).

Methanol Steam Reforming 6 [MSR 6] Electrically Heated Screening Reactor... 

Figure 2.9 Micro structured and modular screening reactor developed at IMM [25] (source IMM).

The mini multi-well batch reactors presented by Desrosiers et al. [45] (Figure 3.12) were applied to the direct amination of benzene to aniline. The screening reactor... 

Figure 3.23 Screening reactor fully made of titanium (left) and with stainless steel (right) with catalysts in separate drawers (middle) (gas distribution section removed) [53] (by courtesy ofAIChE).

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