SCOP system

Membrane permeation-controlled system in which the drug permeation is controlled by a polymeric membrane Transderm-Scop (scopolamine Ciba-Geigy). 

Table 16 describes the predicted performance of the GSHP system. Total amount of extracted heat from the ground reaches 180 GJ and electricity consumption is 13.9 MWh. In this time COP ofthe heat pump unit is 4.4. When this system will adopt a constant—speed pump which can cover the maximum heat output, SCOP is 2.7. This result suggests that a variable speed pump according to the heat loads is effective to improve SCOP. On the other hand, released heat into the ground during summer is 56 GJ and the electricity of 3.6 MWh is consumed to circulate the brine between U-tubes in the foundation piles and ventilation units. SCOP during summer is estimated to be 5.7. This can be also improved. 

N.A. Rhodiola rosea (L.) Scop. Rhodioloside, flavanol glycosides.103-293 Improve learning and memory and reduce stress, anticancer, stimulate the central nervous system. 

A classification system, such as SCOP (Lesk and Chothia, 1984), categorizes structure domains based on secondary structural elements within a protein into a. structure (made up primarily from a helices), / structure (made up primarily from / strands), a// structure (comprised of primarily P strands alternating with a helices), and a + P structure (comprised of a mixture of isolated a helices and / strands). In this classification (Brenner et al, 1996 Lesk, 1991), only the core of the domain is considered. Therefore, it is possible for an all-a structure to have very small amount of p strand outside the a-helical core. Similarly, an all-/ protein may have a small presence of a or 310 helix. The SCOP (http //scop.mrc-lmb.cam.ac.uk/scop/) can be summarized as follows ... 

Transdermal Transderm-Scop transdermal patch system Catapres-TTS transdermal system... 

Scopolamine was the first drug to be marketed as a transdermal delivery system (Transderm-Scop) to alleviate the discomfort of motion sickness. After oral administration, scopolamine has a short duration of action because of a high first-pass effect. In addition, several side-effects are associated with the peak plasma levels obtained. Transderm-Scop is a reservoir system that incorporates two types of release mechanims a rapid, short-term release of drag from the adhesive layer, superimposed on an essentially zero-order input profile metered by the microporous membrane separating the reservoir from the skin surface. The scopolamine patch is able to maintain plasma levels in the therapeutic window for extended periods of time, delivering 0.5 mg over 3 days with few of the side-effects associated with (for example) oral administration. 

Fig. 14 Cross-section view of various structural components in the Transderm-Scop and Catapres-TTS systems.

Scopace tablets, soluble 0.4 mg, Transderm-Scop transdermal system 1.5 mg)... 

There are two main classification systems to organize proteins based on their structure CATH [174] and SCOP [175]. These systems are used to label training data for a number of supervised learning problems found in protein structure prediction. This problem is divided into three subproblems depending on the data... 

Inspection of the Serratia endonuclease structure reveals that its fold differs from other nucleases whose structures are known (28). In the SCOP protein classification system it is listed as the only member of its family (29) In the CATH protein classification system, it is listed as the only member of its tertiary group (20). The dimeric enzyme is almost cylindrical with overall dimensions of 30 A X 35 A X 90 A (Fig. 3). Each monomer consists of a central six-stranded anti-parallel (3-sheet flanked by a-helices on both sides. One long helix, termed... 

SCOP, CATH, and DDD agree on most of their classifications, despite differences in the classification methods they have implemented, and in the rules of protein structure and taxonomy they are based on. Hadley and Jones were the first to publish a detailed comparison of the fold classifications produced by SCOP, CATH, and FSSP. They showed that the three classification systems tend to agree in most cases, and that the discrepancies and inconsistencies are accounted for by a small number of problems. Among these, the domain assignment plays a crucial role. As mentioned, the separation of proteins into domains is a difficult and often subjective process. Many... 

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