Scintigraphy

Somatostatin Receptor Scintigraphy and Receptor-Targeted Radiotherapy... 

Technetium-labelled lipid microspheres were given to patients with ASO (arteriosclerosis obliterans) by intravenous injection, followed by scintigraphy. Technetium accumulated at the sites corresponding to the atherosclerotic lesions (5). 

Figure 9 Distribution of small intestinal transit time in humans. The transit time was measured by y-scintigraphy based on the difference in time between 50% of the drug arriving at the colon and 50% of the drug leaving the stomach. The distribution was constructed from over 400 literature data points. (From Ref. 64 with kind permission from Elsevier Science-NL, Amsterdam.)...

Fig. 8.3. Average transit time in the small intestine measured using y-scintigraphy following administration of various pharmaceutical dosage forms to humans. Data from reference [611-... 

Perkins, A. C., Wilson, C. G., Frier, M. et al., The use of scintigraphy to demonstrate the rapid esophageal transit of the oval film-coated placebo risedronate tablet compared to a round uncoated placebo tablet when administered with minimal volumes of water, Int. J. Pharm. 2001, 222, 295-303. 

Thakur, M.L., and DeFulvio, J.D. (1991) Technetium-99m labeled monoclonal antibodies for immuno-scintigraphy. J. Immunol. Metb. 137, 217-224. 

Charles F, Camilleri M, Phillips SF Scintigraphy of the whole gut Clinical evaluation of transit disorders. Mayo Clin Proc 1995 70 113. 

Exercise tolerance (stress) testing (ETT) is recommended for patients with an intermediate probability of CAD. Results correlate well with the likelihood of progressing to angina, occurrence of acute MI, and cardiovascular death. Ischemic ST-segment depression during ETT is an independent risk factor for cardiovascular events and mortality. Thallium myocardial perfusion scintigraphy may be used in conjunction with ETT to detect reversible and irreversible defects in blood flow to the myocardium. 

CFC, chlorofluorocarbon DPI, dry-powder inhaler HFA, hydrofluoroalkane MDI, metered-dose inhaler UK, unknown. °Lung delivery from in vivo radiolabel scintigraphy or pharmacokinetic studies. 

Mojaverian, P., Chan, K., Desai, A. and Vivian, J. (1989). Gastrointestinal transit of a solid indigestible capsule as measured by radiotelemetry and dual gamma scintigraphy. Pharm. Res. 6 717-722. 

For scintigraphy of the pancreas, an intravenous dose of selenomethionine Se 75 injection, the equivalent of 250 pCi is needed. Express this quantity in bequerels. 

We also conducted a combined scintigraphy and pharmacokinetic study in healthy volunteers, which allowed comparison of the in vivo rates of disintegration and gastric emptying... 

Miller A, Parkman HP, Urbain JC, Brown KL, Donahue DJ, Knight LC, Maurer AH, Fisher RS. Comparison of scintigraphy and lactulose breath hydrogen test for assessment of oro-cecal transit. Dig Dis Sci 1997 42(1) 10-18. 

Scintigraphic techniques have proven to be useful when investigating the in vivo behavior of liposomes. The major advantage of scintigraphy is the ability to obtain noninvasive quantifiable images at many time points in either humans or animals. This rapidly provides the in vivo behavior of the liposomes. 

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