Y-Scintigraphy

Figure 9 Distribution of small intestinal transit time in humans. The transit time was measured by y-scintigraphy based on the difference in time between 50% of the drug arriving at the colon and 50% of the drug leaving the stomach. The distribution was constructed from over 400 literature data points. (From Ref. 64 with kind permission from Elsevier Science-NL, Amsterdam.)...

Fig. 8.3. Average transit time in the small intestine measured using y-scintigraphy following administration of various pharmaceutical dosage forms to humans. Data from reference [611-... 

In vivo methods, which are few, measure the residence time of bioadhesives at the application site [47]. Techniques like y-scintigraphy, the perfused intestinal loop and radiolabeled transit studies using Cr-labeled bioadhesive polymer [48] and Tc-labeled polycarbophil [49] have been employed for this purpose. 

Wilding IR, Coupe AJ, Davis SS. The role of y-scintigraphy in oral drug delivery. Adv Drug Del Rev 1991 7 87-117. 

Figure 3.3 Human small intestinal transit time of different pharmaceutical dosage forms measured by y-scintigraphy [40]. The intestinal transit time is fairly fixed and largely independent of the physical properties of the system or food intake.

Takemura S, Watanabe S, Katsuma M, Fukui M. Human gastrointestinal transit study of a novel colon delivery system (CODES ) using y-scintigraphy. Proceedings of the International Symposium on Controlled Release of Bioactive Material, Paris, Vol. 27, 2000. 

Erdogan, S., Roby, A., Torchilin, V.P., 2006. Enhanced tumour visualization by y-scintigraphy with In-labeled polychelating-polymer-containing immunoliposomes. Molecular Pharmaceutics 3, 525—530. 

Fig. 23 ln-DTPA-Bz-SA-Lys(IRDye800)-c(KRGDf) in nude mice visualised by (from left to right) white light, y-scintigraphy and NIR. ... 

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