Schultz, Peter

HERMAN S. SCHULTZ, PETER G. ALDEN, and JURIS L. EKMANIS Waters Associates, Milford, MA 01757... 

Paul V. R. Schleyer Tamar Schlick Peter R. Schreiner John L. Schultz Peter Schwerdtfeger George Seibel... 

In 1986, Richard Lerner and Peter Schultz independently reported antibody catalysis of the hydrolysis of aryl esters and of carbonates, respectively (Pollack et al., 1986 Tramontano et al., 1986). Reactions of this type are well... 

In addition to using auxotrophic strains of naturally occurring amino acids, the laboratory of Peter Schultz has developed very elegant methods to incorporate labeled amino acids in specific positions of a protein by extending the genetic code of prokaryotic as well as eukaryotic cells [26,27]. The... 

Freemerman AJ, Turner AJ, Birrer MJ, Szabo E, Valerie K, Grant S (1996) Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C. Mol Pharmacol 49 788-795 Freund A, Boos J, Harkin S, Schultze-Mosgau M, Veerman G, Peters GJ, Gescher A (1998) Augmentation of l-beta-D-arabinofuranosylcytosine (Ara-C) cytotoxicity... 

Other scientists besides biomedical researchers have employed combinatorial chemistry. In 1995, X.-D. Xiang and Peter G. Schultz, then at the University of California, Berkeley, and their colleagues published a paper in Science describing a pioneering application of this technique in materials research. As described in A Combinatorial Approach to Materials Discovery, Schultz and his colleagues performed parallel synthesis—a lot of reactions at the same time—to make an ar-... 

UC Berkeley chemist Peter Schultz described how to combine... 

Freiermuth B, Hellrung B, Peterli S, Schultz M-F, Wintgens D, Wirz J. Helv. Chim. Acta 2001 84 3796-809. 

In 1986, Richard Lerner (Scripps Institute, La Jolla/CA, USA) and Peter Schultz (then at the University of California Berkeley, now also at the Scripps Institute), independently of each other, delivered proof of the concept that catalytic antibodies exist. 

S. Goletz, B. Thiede, F.-G. Hanisch, M. Schultz, J. Peter-Katalinic, S. Muiller, O. Seitz, and U. Karsten, A sequencing strategy for the localization of O-glycosylation sites of MUC1 tandem repeats by PSD-MALDI mass spectrometry, Glycobiology, 7 (1997) 881-896. 

Peter Schultz s team used a combinatorial library of purines to identify agents that could disassemble multinucleated myotubes into mononucleated fragments (a morphological differentiation screen). A new microtubule-binding molecule, mysoseverin, was identified in this way [19]. 

Chen S, Takanashi S, Zhang Q, Xiong W, Zhu S, Peters EC, Ding S, Schultz PG. Reversine increases the plasticity of lineage-committed mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 2007 104 10482-10487. 

A particular form of CNB is (2-nitrophenyl)glycine (Npg). This artificial amino acid (Npg, Fig. 3.2-ID) was successfully incorporated into ion channels like the nicotinic acetylcholine receptor [22] by nonsense suppression, a technique developed by Peter Schultz and coworkers [23-26]. Irradiation (4 h, >360 nm) of proteins containing Npg led to peptide backbone cleavage in Xenopus oocytes [22],... 

The elegant and sophisticated - yet laborious - biosynthetic methodology introduced by Peter Schultz made a wider exploration of protein functions possible by de facto expanding the natural genetic code [23-25]. 

Schultz IR, Peters EL and Newman MC (1996) Toxicokinetics and disposition of inorganic mercury and cadmium in channel catfish after intravascular administration. Toxicol Appl Pharmacol 140 39— 50. 

---