Scaffolding approach

Wu, X., Ding, Q., Schultz, P. G. (2002) A combinatorial scaffold approach toward kinase-directed heterocycle libraries. J Am Chem Soc 124, 1594-1596. 

McCubbin JA, Maddess ML, Lautens M (2006) Total Synthesis of Cryptophycin Analogues via a Scaffold Approach. Org Lett 8 2993... 

As already mentioned (Section 2.1), the preparation of p-D-gulo- and P-D-allo-configured carbapyranosyl thiols 273 and 274 utilized thiolactone 269 as an advanced chiral scaffold. Approaching the decisive annulation step, which creates the carbapyranose ring, the required aldehyde 270 was implemented from 269 via silylation and Swem oxidation. 

An alternative arm-and-scaffold approach to DCC-based identification of G-quadruplex binders was reported in 2008 by Nielsen and Ulven [16]. Here, mono-, di-, and tritopic scaffolds 8, 9, and 10 were combined with side chain disulfides J-L (Fig. 7), the molar ratio of each scaffold being adjusted to reduce... 

Fig. 7 Side-chain and scaffold approach to G-quadruplex targeted DCC...

This approach of using an aromatic residue can be considered as a scaffold approach in which functional groups are attached to a relatively rigid core ( scaffold ) thereby position-... 

The PDL model adopted at the BME Department at KU is based on the system designed by GT in terms of the core problems described above. As previously mentioned, other attributes such as the scaffolding approach, the three problems per semester stmcture as well as the general course stmcture were also maintained. On the other hand, what we refer to as skins or outer shells affixed to these open-ended, ill stmctured, and poorly constrained core problems were specifically designed to custom-fit the KU and the UAE culture. 

Extremely Thin Absorber-Host-Scaffold Approach... 

It can be seen from Table VIII that biodegradable polymer scaffolds approach went faster into clinical practice than the other two. Synthetic scaffolds enable us better control over physical properties such as mechanical properties. Also varieties of surface modification methods like protein and peptide immobilization, plasma treatment can provide better biocompatibility to the original polymer materials. 

Education research has shown that a scaffolded approach helps students develop independent, expert skills. How might we provide enough scaffolding to support students as they explore such options, without oversimplifying the challenge before... 

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