Scaffold-hopping approach

FIGURE 15.56 Design of a novel CCK2 antagonist via a scaffold hopping approach from a known series of indoles. 

Sun, H., Tawa, G., and Wallqvist, A (2012) Classification of scaffold hopping approaches. Drug Discovery Today, 17, 310-322. 

Targeting Onchocerca Volvulus Chitina e-1 (OvCHTI) using the Hydroxytriazole Moiety within a Scaffold Hopping Approach... 

The results of this study demonstrate the potential utility of scaffold hopping approach in designing new antitubercular analogs of carbazole with appended... 

Schneider et al. [125] developed and applied CATS descriptors as topological pharmacophores for scaffold hopping. This approach led to the prediction of novel cardiac T-type Ca channel blocking agents using mibefradil as starting structure. 

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