Saturated fatty acids coagulation

Platelets and blood coagulation are also influenced by lipids and fatty acids. Saturated fatty acids are activators of the "contact factor" in the intrinsic clotting system and exert an influence on the activation of platelets, as do prostaglandins (E.F. Lxischer). Phospholipids of red blood cells and phospholipids and fatty acids of platelets may differ in nutritionally different areas (Cincinnati, Ohio Milan and Palermo, Italy) and the lipid composition of platelets may have an effect on their function the nutritional state may predispose to thrombogenic phenomena (J.M. lacono et al.). 

Saturated fatty acids can affect the plasma activity of some of these coagulation and fibrinolytic factors... 

Coagulation The interest in the effects of particular fatty acids on coagulation and fibrinolytic factors has increased since the observation that different saturated fatty acids raise serum lipids and lipoproteins in different ways (see section on cholesterol metabolism). Although results are conflicting, some studies indicate that the most potent cholesterol-raising saturated fatty acids also increase factor VII activity. 

Diets rich in lauric plus myristic acids compared with a diet rich in stearic acid also increase concentrations of other vitamin K-dependent coagulation proteins. In addition, this mixture of saturated fatty acids raised FI + 2 concentrations, indicating increased in vivo turnover of prothrombin to thrombin. This agreed with a study in rabbits where increased FI + 2 concentrations were associated... 

The insoluble surface slicks and thicker films of organic matter are interesting. On the open sea, these thin layers probably are primarily of natural origin and consist of C8-Cj2 fatty acids (both saturated and unsaturated), esters, alcohols, olefins, and alkanes (17, 18, 19, 20,16). Natural petroleum seeps, fats from decaying plants and animals, rainout from air, and coagulation of soluble organics by rising bubbles represent potential sources (21). 

Isolated platelet phosphatides, especially the serine phosphoglycer-ide family, can replace the entire platelet in in vitro coagulation tests but the lipid itself is not as eiBcient as lipoprotein particles derived from platelet membranes or granules. Although the molar ratio of saturated to unsaturated fatty acids in platelet phosphatides is unity, there are large amounts of long-chain, highly unsaturated fatty acids present. 

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