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Salts of drugs

Table 3.1 Examples of the acids and bases used to form the salts of drugs ... Table 3.1 Examples of the acids and bases used to form the salts of drugs ...
Giron, D. (2003), Characterization of salts of drug substances,/. Thermal Anal. Calor., 73, 441 157. [Pg.973]

However, factors such as the solubility product (Ksp) of the salt, common-ion effects, and hygroscopi-city may disfavor the salts of first choice using the above criterion, e.g., hydrochloride or sodium salts. The formation of hydrochloride salts does not always enhance solubility above that of the free base. The lower solubility of a hydrochloride salt in dilute HCl, relative to that of the free base, is attributed to the common ion effect of the chloride ion on the solubility product equilibrium of the salts. The common-ion effect suppresses the solubility product equilibrium. This is particularly relevant to the HCl salts of drugs administered orally, resulting in contact with... [Pg.3178]

In the preformulation study, the comprehension of physicochemical properties regarding water-solid surface interaction is beneficial to the handling, formulation, and manufacture of the finished products. Data on sorption/de-sorption isotherm, hydration of salts of drug product, water sorption of pharmaceutical excipients, and kinetics of water adsorption or desorption of a substance can be obtained effectively by the dynamic vapor sorption method. The knowledge may be utilized for dosage form design and supports the understanding of the mechanism of action. [Pg.194]

Rubin JT. Solubilities and solid state properties of the sodium salts of drugs. J Pharm Sci 1989 78 485-489. [Pg.129]

To reiterate, water solubility of molecules with ionization centers is dependent on pH. The salts of drugs may be soluble in water, but once in solution, the solubility of such molecules depends on the pH. Neutral molecules can be extracted... [Pg.106]

COLORANTS FORFOOD,DRUGS,COSTffiTICS AND TffiDICALDEVICES] (Vol 6) Disodium salt of tetrabromophthalate... [Pg.336]

Color Additives. The FDA has created a unique classification and strict limitations on color additives (see also CoLORANTS FOR FOOD, DRUGS, COSMETICS, AND MEDICAL DEVICES). Certified color additives are synthetic organic dyes that ate described in an approved color additive petition. Each manufactured lot of a certified dye must be analyzed and certified by the EDA prior to usage. Color lakes are pigments (qv) that consist of an insoluble metallic salt of a certified color additive deposited on an inert substrate. Lakes are subject to the color additive regulations of the EDA and must be certified by EDA prior to use. Noncertifted color additives requite an approved color additive petition, but individual batches need not be EDA certified prior to use. [Pg.286]

It has long been known that quaternary ammonium salts can exert a curare-like action, and in recent years much attention has been given to the synthesis and pharmacological testing of such products work on this subject up to 1936 has been reviewed by Ing, and more recently a theoretical discussion of the relationship between structure and action in drugs of this type has been provided by Holmes, Jenden and Taylor.Chase, Lehmann and Yonkmann have compared the action of quaternary salts of quinine with that of -erythroidine hydrochloride and of dihydro- -erythroidine hydrobromide. Quinine ethochloride shows marked curariform action of short duration. ... [Pg.392]

None of the quaternary salts of the cinchona alkaloids have given promising results as pneumococcicidal agents, but quinine methochloride and ethochloride have received some attention recently as curarising drugs. ... [Pg.479]

Octasodium salt of octa-4,5-dicarboxyphthalocyanin cobalt(II) combined with ascorbic acid (teraphthal) as a new drug for binary catalytic therapy of malignant tumors 98MI57. [Pg.233]

Further substitution of benzoic acid leads to a drug with antiemetic activity. Alkylation of the sodium salt of p-hydroxy-benzaldehyde (8) with 2-dimethylaminoethyl chloride affords the so-called basic ether (9). Reductive amination of the aldehyde in the presence of ammonia gives diamine, 10. Acylation of that product with 3,4,5-trimethoxybenzoyl chloride affords trimetho-benzamide (11). ... [Pg.110]

Aromatic biguanides such as proguanil (181) have been found useful as antimalarial agents. Investigation of the metabolism of this class of drugs revealed that the active compound was in fact the triazine produced by oxidative cyclization onto the terminal alkyl group. The very rapid excretion of the active entity means that it cannot be used as such in therapy. Consequently, treatment usually consists in administration of either the metabolic precursor or, alternately, the triazine as some very insoluble salt to provide slow but continual release of drug. [Pg.280]

Inclusion of fluorine on the pendant aromatic ring and the basic side chain seems to emphasize the anticonvulsant and hypnotic effects of this class of drugs. Thus alkylation of the benzodiazepinone, 24 (prepared from the corresponding substituted aminobenzophenone), with 2-chlorotriethylamine via its sodium salt affords fluazepam. ... [Pg.366]

In order to avoid as far as possible double bond positional isomers, a problem quite common in drugs with indene moieties, N-trityl-2-hydroxymethylmorpholine (23) was reacted with the potassium. salt of 4-hydroxy-1-indanone (24) in DMSO solvent to give condensation product 25 in good yield. Reduction of 25 with LLAIH produced the hydroxyindane which was dehydrated and deprotected with HCl to give indeloxazine (26) [8]. [Pg.59]

The reaction of enamines with iminium salts provides an alternative route to Mannich bases which are an attractive class of compounds, since they have found many applications (synthesis of drugs, pesticides, synthetic building blocks, etc.). This methodology has several basic advantages compared to the classic aminomethylation procedure15-18-24 ... [Pg.775]

In theory, one could utilise GC-A ligands to lower blood pressure and to reduce blood volume as they increase the excretion of water and salt. Nesiritide, human recombinant BNP, is the first member of this new class of drugs approved for the initial intravenous treatment of acutely decompensated congestive heart failure. Whether nesiritide can be a valuable addition to the standard therapy of decompensated heart failure remains to be demonstrated. [Pg.575]


See other pages where Salts of drugs is mentioned: [Pg.603]    [Pg.109]    [Pg.418]    [Pg.324]    [Pg.686]    [Pg.688]    [Pg.3186]    [Pg.3951]    [Pg.239]    [Pg.758]    [Pg.217]    [Pg.58]    [Pg.758]    [Pg.104]    [Pg.603]    [Pg.109]    [Pg.418]    [Pg.324]    [Pg.686]    [Pg.688]    [Pg.3186]    [Pg.3951]    [Pg.239]    [Pg.758]    [Pg.217]    [Pg.58]    [Pg.758]    [Pg.104]    [Pg.366]    [Pg.403]    [Pg.274]    [Pg.79]    [Pg.140]    [Pg.190]    [Pg.282]    [Pg.148]    [Pg.177]    [Pg.275]    [Pg.225]    [Pg.154]    [Pg.611]    [Pg.141]    [Pg.119]   


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Drug salts

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