Salmonella resistance

Shi, Y., Cromie, M., Hsu, F., Turk, J., Groisman, E. PhoP-regulated Salmonella resistance to the antimicrobial peptides magainin 2 and polymyxin B. Mol Microbiol 53 (2004) 229-241. 

Mellon AA, Hassani L (1999) Antibiotic resistance of Salmonella strains isolated from children living in the wastewater-spreading field of Marrakesh city (Morocco). World J Microbiol Biotechnol 15 81-85... 

Kieboom J, T Abee (2006) Arginine-dependent acid resistance in Salmonella enterica serovar Typhimurium. J Bacterial 188 5650-5653. 

These examples illustrate the power of proper ANN feature space optimization. In all the examples discussed, the limits of the type of information that could be gleaned from the Salmonella PyMAB spectra were probed. The PD-ANN s automated optimization removed the issue of methodological uncertainty and enabled a focus on questions of Py-MAB-MS spectral information content and its potential use for rapid strain ID. Question Does Py-MAB-MS data support Serovar classification Answer Yes. How about PFGE classification Yes. How about antibiotic resistance profile Answer Perhaps, if one first eliminates stronger contributions to spectral variation and then, by design and grouping, limits the possibilities to only a few classes. 

Coldham, N. G. Woodward, M. J. Characterization of the Salmonella typhimurium proteome by semi-automated two dimensional HPLC-mass spectrometry Detection of proteins implicated in multiple antibiotic resistance. J. Proteome Res. 2004, 3,595-603. 

More recently, a range of other quality and safety issues have been recognised by consumers and now influence poultry meat and egg buying patterns and behaviour. Most importantly this includes (i) the routine use of antibiotics as growth promoters and curative medicines and the potential for development of transferable antibiotic resistance, (ii) risk associated with enteric pathogen (e.g. Salmonella and Campylobacter) and toxin (e.g. dioxin) contaminants of poultry products, (iii) the environmental impact of poultry production and (iv) the sensory and nutritional quality of eggs and poultry meat (Menzi et al., 1997 Hamm et al., 2002 Rodenburg et al., 2004 Horsted et al., 2005). 

Fact Sheet 139 Drug-Resistant Salmonella. Geneva Health Communications and Public... 

Upper respiratory irritation, reduced resistance to infection by Salmonella, and increased pulmonary macrophages all effects disappeared by day 63 No adverse effects noted at low concentration. At 3700 pg/L, histopathology of lung, liver, and kidney... 

Human microbial pathogens that possess the ability to adhere to host tissues have a distinct advantage over those that do not, in that they are better equipped to evade and resist the defense systems of their host. There are numerous adherence mechanisms that have been described to date. However, those that are most commonly studied originate from pafhogens that colonize the GIT and genital-urinary tract, including Salmonella, H. pylori, and pathogenic serotypes of E. coli. 

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