Saccharomyces cerevisiae sphingolipids

Molecular targets have been elucidated for Dm-AMPl and Rs-AFP2. Dm-AMPl was found to bind plasma membranes from Neurospora crassa and Saccharomyces cerevisiae in a saturable manner and it competed with closely related defensins for binding. Mutational studies with S. cerevisiae identified lipid raffs containing sphingolipids as a molecular target " while glycosylphosphatidylinositol (GPI)-anchored proteins could be... 

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Figure 12.16 Sphingolipid biosynthesis in Pichia ciferrii. Enzymes are shown as ovals and named according to the corresponding homologues from Saccharomyces cerevisiae. Abbreviations AcTR, acetyl-CoA long-chain base acetyltransferase TAPS, tetraacetyl phytosphingosine TriASa, triacetyl sphinganine TriASo, triacetyl sphingosine IP, inositol phosphoryl. TAPS is by far the most abundant sphingolipid formed in wild-t5 e cells, as reflected by the strength of the arrows.

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Dickson, RC and Lester, RL (1999) Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. Biochint Biophys Acta, 1438, 305-321. 

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Thevissen, K., Francois, I.E., Takemoto, J.Y., Ferket, K.K., Meert, E.M., and Cammue, B.P. (2003b) DmAMPl, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae. FEMS Microbiol Lett 226 169-173. 

Guan, X.L. and Wenk, M.R. (2006) Mass spectrometry-based profiling of phospholipids and sphingolipids in extracts from Saccharomyces cerevisiae. Yeast 23, 465-477. 

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