Round cell infiltrate

Fig. 22.2 Subsiding acute viral hepatitis A with lytic loss of hepatocytes and round-cell infiltrates...

Fig. 22.14 Scarred area with fragmented parench)mial islets (- ) after confluent necrosis in the wake of viral hepatitis B (HBsAg+). Localized round-cell infiltration in the remaining parench)Tnal areas (HE)...

The transmission of Tryp. cruzi is caused by reduviid bugs, which excrete infectious trypanosomes in their faeces. These enter the body through small skin or mucosal lesions. They cause the South American sleeping sickness , also called Chagas disease (C. Chagas, 1908). In the liver only portal round-cell infiltrates are found. 

Fig. 32.9 Primary biliary cholangitis with cirrhotic transformation. Well-rounded parenchymal residues surrounded by collagenous fibre tissue hardly recognizable bile ducts in the residual round cell-infiltrated portal fields (stages III—IV) (HE)...

Muscle necrosis and round cell infiltrates have been seen in histological studies of animal muscle recently injected with phenol, but not after a few months have passed (36). 

Fig. 12. Paraffin sections of rat liver, periodic acid Schiff stain X22. A, normal liver of control animal killed 24 h after injection of 1 ml of seasame oil i.p. B, extensive centrolobular necrosis of parenchymal cells in rat killed 24 h after administration of high dose of bromobenzene (0.2 ml i.p.). C, Liver 24 h after lower dose of bromobenzene (0.03 ml i.p.). The centrolobular areas exhibit some small patches of round cell infiltration and decreased glycogen staining in the cytoplasm after hepatocytes but little necrosis. D, Extensive centrolobular necrosis after administration of the same low dose of bromobenzene (0.03 ml i.p.) to a rat treated with pheno-barbital (20 mg/kg) for 3 days in order to induce hepatic microsomal enzymes. After Brodie et al...

These results were confirmed by Caira et al. (85,133), who found gallstones in New Zealand rabbits of both sexes fed 0.5 g cholestanol for 9 days or more. They observed that the newly formed stones were gelatinous in consistency and were accompanied by marked mucosal inflammatory changes (edema, round cell infiltration, and fibrosis). Choledocholithiasis developed readily in cholecystectomized animals, indicating that the liver bile itself was abnormal and that a gallbladder was not essential for stone formation. Similar concretions formed in two of 20 guinea pigs fed 0.25 g cholestanol daily, but none formed in rats fed 0.125 g daily. 

There was diffuse, zonal, or focal fibrosis in 25 cases. Round cell infiltration was observed in 28 cases (Figs. 13 and 14). 

Fig. 1 shows a liver biopsy of a 7 week old infant (J.M.) with intestinal atresia, who had been treated with parenteral nutrition for the previous 6 weeks. There is evidence of cholestasis and infiltration of the portal triad. The patient was rebiopsied at 16 weeks of age while still continuing on intravenous nutrition. A round cell infiltrate in the portal area with some fibrous tissue was noted. A third biopsy performed at six months of age while the child was still being maintained on parenteral nutrition revealed the continued presence of fibrous tissue and a round cell infiltrate in the portal triad. 

L.G., an 18 year old with granulomatous ileocolitis treated for 14 days with parenteral nutrition had a percutaneous menghini needle liver biopsy after clinical and chemical abnormalities suggested early hepatic disease. Fig. 2 represents a high power view of the biopsy specimen showing evidence of a focal round cell infiltrate with mild to moderate steatosis. 

Fig. 2. Section of a percutaneous liver biopsy from patient L.G. after 2 weeks of parenteral alimentation showing evidence of focal round cell infiltration with mild steatosis.

Fig. 75. Portion of the myocardium of a rat on a vitamin E-deficient diet for more than a year. Note loss of myocardial fibers, round-cell infiltration, and fibrosis.

After 9 hours there are numerous clusters of spongiosis in the epidermis and a very clear dermal infiltrate composed largely of lymphocytes (round cells). With the alkaline phosphatase reaction, we again observe that there are clusters of inhabited as well as non-inhabited spongiosis (Figs. 10 and 11). 

In some sections more or less extended epidermal necrosis and detachment of the epidermis are seen, in others intra-epidermal abcesses may be observed. In the upper dermis, the small vessels are dilated and there are extravasations. The infiltrate is very extensive, being composed of small round cells, connective tissue cells, and eosinophils. The eosinophils are intra- and perivascular. We cannot say, as we did in the sensitization with CA, that the infiltrate is largely composed of eosinophils, but we can affirm that these are much more numerous than in the sensitization with DNCB. 

We then wondered if there would be a histological difference between the 2 tests, since, as we have seen, the infiltrate with the CA test in guinea pigs sensitized only to CA, is largely composed of eosinophils while the infiltrate of the test with DNCB in guinea pigs sensitized only to DNCB is composed largely of small round cells (lymphocytes). 

Fibers and filaments with larger microchannels, deep grooves, as well as hollow fibers induce improved capillary action that, in addition to adsorption phenomenon onto fiber surface, encourages cells adhesion but also cell infiltration and migration compared to round section fibers. Fiber topography is thus a tunable parameter to control cell migration, either to promote or restrict it. 

Centroblastic-centrocytic lymphomas This tumour type also develops from lymphatic germ centre cells. Liver involvement occurs in about 30% of cases. The portal fields are rounded due to infiltration the limiting plates are penetrated in places. Follicular structures can occasionally be recognized. 

---