Rotor granulator

Figure 9. Coating in fa) a conventional fluid bed granulator and (b) a rotor granulator.

Schmidt, W.G. Mehnert, W. Frdmming, K.-H. Controlled release from spherical matrices prepared in a laboratory scale rotor-granulator—release mechanism interpretation using individual pellet data. Eur. J. Pharm. Biopharm. 

An alternative batch spray granulation process utilises the fluidised bed rotor granulator for the manufacture of spherical flavour granules. In this case a flavouring emulsion is sprayed into a fluidised bed of core material. 

Korakianti ES, Rekkas DM, Dallas PP, Choulis NH. Optimization of the pelletization process in a fluid bed rotor granulator using experimental design. AAPS PharmSdTech 2000 l(4) article 35. 

A similar phenomenon was reported by Maganti and Celik when pellets produced by rotor granulation were compressed (65). They compared the compaction behavior of pellet formulations, mainly consisting of MCC, to that of the powders... 

Figure 1 Schematic representation of some industrial granulators, (a) Conventional fluid bed granulator, (b) Conventional spouted bed granulator, (c) Spouted bed with draft tube, (d) High shear rotor granulator.

The ring-type granulator Penn.sylvania Cru.sher Corp.) features a rotor assembly with loose crushing rings, held outwardly by centrifugal force, which chop the feed. It is suitable for highly friable materials which may give excessive fines in an impact miU. For exam-... 

Bottom Spray Wurster 2. Top Spray [Granulator) S.Tangenlial Spray (Rotor- processor)... 

The tangential-spray, or rotor, process, originally designed as a granulator for producing spheronized granulates... 

The rotor in.sert (Fig. 7) was conceived as a combination of a high shear mixer/granulator and fluidized bed dryer. In contrast with a traditional fluid bed dryer, the base of the product container is fitted with a solid rotating disc as oppo.sed to a perforated air distribution plate and fine screen. The disc height may be adjustable to allow the control of... 

Fig. 5 illustrates the granule particle size distribution as a function of gap size between rotor and stator. As can be seen, the average particle size D(50) is approximately equal to the gap size, and the particle size span (ca. 0.5) is very low and independent of gap size. Typically, the concentration of the binder is 25wt%. In all of the known agglomeration and microencapsulation techniques, the concentration of... 

Fig. 5 Granule size distribution as a function of gap (clearance) between the rotor and stator disks. Average granule size )(50) in mm and particle size span are also indicated. (From Ref (View this art in color at www.dekker.com.)...

Figure 145. Effect of Schugi rotor speed on granule size distribution ...

Figure 317. Sectional drawing of a basket-type granulator with vertical rotor axis. (BR Granulator )...

Figure 318. Photograph of a small basket-type granulator with horizontal rotor axis. (Courtesy of Erweka, Heusenstamm, FRG)...

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