Spray granules

Figure 24. Effects of conventional dense phase conveying and vibration assisted conveying on the particle size distribution of spray granules (the vertical bars indicate the confidence intervals. (Molerus et al., 1989.)...

Mortensen S. and Hovmand S. in Fluidization Technology, Volume II, Keairns D. L. (ed.) page 519. Particle formation and agglomeration in a spray granulator. (Hemisphere, Washington, 1976). 

Harkonen, H., Koskinen, M., Linko, R, Siika-aho, M. and Poutanen, K., Granulation of enzyme powders in a fluidized bed spray granulator, Lebensmittel Wissenschaft Technologie, 26 (1993) 235-241. 

Figure 7.21 Schematic illustration of nucleation and growth process in spray granulation of = 1 xm alumina. From J. S. Reed, Principles of Ceramics Processing, 2nd ed. Copyright 1995 by John Wiley Sons, Inc. This material is used by permission of John Wiley Sons, Inc.

The granules from spray granulation or spray drying can then be used for pressing, though any one of a number of additives is typically used prior to forming. The liquid... 

SCALE-UP OF THE CONVENTIONAL FLUIDIZED BED SPRAY GRANULATION PROCESS... 

Table 3 Major and Minor Process Variables to Be Considered in Fluidized Bed Spray Granulation...

As stated earlier, a typical air velocity used for spray granulation is from l.Om/sec to 2.0m/sec. 

Table 2 is based upon the psychrometric chart which gives a first guess at determining the proper spray rate for a spray granulation process in a fluid-bed processor. Table 2 shows the relationship between the air flow and binder spray rate and inlet air temperature which can be used as a starting point to set process parameters when considering the fluid-bed granulation process. 

Use 100% outlet RH for spray granulator or 30-60% RH (as required for column coating)... 

A spray granulation process was developed for a common pharmaceutical compound. The granulation process involved spraying of a 5% w/w binder solution onto the fluidized powder. Table 5 shows the data from the 15 kg run and resultant successful 150-kg run condition for a spray agglomeration process (138). 

Liske T, Mobus W. The manufacture and comparative aspects of fluidized layer spray granulation. Drugs made in Germany 1968 XI 182-189. 

Bonck JA. Spray granulation presented at the AlChE Annual Meeting, November, 1993. 

Bonck, J. A., Spray granulation. Presented at the AIChE Annual Meeting, November 1993, pp. 

Bottom Spray Wurster 2. Top Spray [Granulator) S.Tangenlial Spray (Rotor- processor)... 

B. Continuous Process of Graining (Spray Granulation or Prilling (Refs 104 118). 

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