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Roller compaction technology

Bristol-Myers Squibb Company, New Brunswick, New Jersey, U.S.A. [Pg.159]

This chapter is different from the original new works, findings, and best practices from various investigators since 1997 have been added. The interested reader will have to wait for a comprehensive book (in preparation now) to link numerous journal articles, chapters, and investigative works for technology completeness. [Pg.159]


Wet Granulation Technology vs. Slugging Technology vs. Roller Compaction Technology... [Pg.243]

Miller RW. Roller Compaction Technology. In Handbook of Pharmaceutical Granulation Technology. Chapter 6. New York Marcel Dekker, 1997 99-150. [Pg.265]

Miller RW, Sheskey PJ. A survey of current industrial practices and preferences of roller compaction technology and excipients Year 2000. Am Pharm Rev 2001 4(l) 24-35. [Pg.265]

Miller RW. 1997. Roller compaction technology. In Parikh DM, editor. Handbook of pharmaceutical granulation technology. New York Marcel Dekker. [Pg.157]

A number of these attributes, best technology practices and features, were rated for their industrial and pharmaceutical importance and reported by Miller and Sheskey in 2001. Ultimately, today s roller compaction technology offers a continuous process with better process controls, manufacturing efficiencies, and environmental protection than an archaic slugging process technology. [Pg.3160]

Roller Compaction Technology for the Pharmaceutical Indnstry Table 5 Operating parameters and results of compactor machine design 1 when compacting poor flowing low density active drug substance ... [Pg.3172]

Miller, R.W. Roller compaction technology. In Handbook of Pharmaceutical Granulation Technology Parikh, D.M., Ed. Marcel Dekker, Inc. New York, 1997 VoL 81, 99-150. [Pg.3175]

Miller, R.W. Sheskey, P.J. Survey of current industrial 24. practices and preferences of roller compaction technology and excipients year 2000. Am. Pharm. Rev. 2001, 4 (1),... [Pg.3176]

Miller, R.W. Vacuum Deaeration Advances in Pharmaceutical Roller Compaction Technology. Proceedings of the 24th Institute for Briquetting and Agglomeration, October 1995 Vol. 24, 165-173. [Pg.3176]

Methods Nos. 1 and 2 in Table 132, in which the disintegrant is added after granulation, are used most frequently. In Methods Nos. 3 and 4, the disintegrant is added prior to granulation, while in Nos. 5 and 6 part of the disintegrant is added before, and the rest after granulation. Direct compression, Method No. 7, can also be used. The application of crospovidone in the roller compaction technology (Method No. 6) is described in the literature [650,651]. [Pg.151]

This chapter briefly identifies key aspects of roller compaction technology. Unlike the slugging proeess technology, roller compaction technology is well suited for dry granulation agglomeration in the era of modern development of active pharmaceutical ingredients in pharmaceutical plants. [Pg.161]

A history of hopper and feed screw designs showed that each design evolved to facilitate and improve powder flow to the compactor feed screw conveyance system. Feed hopper designs shown in Roller Compaction Technology for the Pharmaceutical Industry depict designs used in older compactor models (23). Dehont et al. described the powder compaction feeding systems that were in use up to 1989 (24). [Pg.167]

Sizing devices are now trimly fitted to the compactor body and controlled by variable speed drives. Most compacters no longer require a separate milling machine in tandem to size compacts as required by slugging technology. Roller compactors have clean-in-place systems that offer environmental and safety features. These systems minimize human exposure to chemicals. See Roller Compaction Technology for the Pharmaceutical Industry for additional information (23). [Pg.167]


See other pages where Roller compaction technology is mentioned: [Pg.237]    [Pg.238]    [Pg.238]    [Pg.243]    [Pg.3159]    [Pg.3160]    [Pg.3160]    [Pg.3161]    [Pg.3162]    [Pg.3163]    [Pg.3164]    [Pg.3165]    [Pg.3166]    [Pg.3167]    [Pg.3168]    [Pg.3169]    [Pg.3170]    [Pg.3171]    [Pg.3173]    [Pg.3174]    [Pg.3175]    [Pg.3176]    [Pg.3214]    [Pg.4096]    [Pg.410]    [Pg.159]    [Pg.161]    [Pg.161]    [Pg.163]    [Pg.165]    [Pg.167]    [Pg.169]   


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