Role of the Drugs

Know the role of the drug target and how its activity is screened... 

Although these approaches demonstrate the important role of the drug material s surface and its morphology on dictating the dissolution profile, they still suffer from limitations regarding the shape and size distribution of particles as well as the assumptions on the constancy of the diffusion layer thickness S and the drug s diffusivity V throughout the process implied in (5.5), (5.6), (5.7), and... 

Safety information should be presented as a summary of adverse experiences by frequency and body system, except for patients who died or who left the study prematurely because of an adverse event. These should be described in detail, and the role of the drug should be evaluated for each reaction. The safety analysis should consider abnormal laboratory values as well as adverse experiences, and the following points should be kept in mind ... 

In the first case the presentation was strongly suggestive for a causative role of the drug. In the second it was speculated that the condition might have been provoked by altered GABAergic transmission after gabapentin withdrawal. 

Headache, drowsiness, lowered mental acuity, and other psychiatric effects can be caused by sulfonamides (606). However, these adverse effects are rare, and the causative role of the drug is usually not clearly established. 

To appreciate the role of the drugs chemist in drugs analysis. 

Myasthenia gravis has been reported during the use of bucillamine (4). However, since the disease persisted after withdrawal, the role of the drug was uncertain. 

In the last report, the causative role of the drug is difficult to assess, because no mention was made of whether myoclonus regressed after reducing the dosage. 

A causative role of the drug could not be determined with certainty in this case. 

For new investigational compounds, it is the role of the drug-developing company to reserve a specific lot, which is subject to... 

Describe the relationship of dose and therapeutic levels to the role of the drug receptor. 

In this design, the adhesive performs the role of the drug reservoir. The drug and excipients are formulated into the adhesive, typically into adhesive solution, and the solvent is evaporated to yield the matrix film. The matrix-adhesive film is then laminated to a backing film. 

M. MilMn, I. Caraballo and A.-M. Rabasco, The role of the drug/exdpient particle size ratio in the percolation model for tciblets, Pharm. Res., 15 (2) 216-220,1998. 

A further patient has been reported with quinidine-induced liver damage the causal role of the drug was confirmed by rechallenge. Liver biopsy showed an active hepatitis with focal areas of hepatocellular necrosis around which were scattered lymphocytes, plasma cells and polymorphonuclear leukocytes (33 ). 

---