Role of Innate Immune Response in Allotransplant Rejection

Adhesion molecules also play a crucial role in allograft rejection. The migration of activated T cells from secondary lymphoid organs to the graft site is regulated by adhesion molecules. Furthermore, these molecules are pivotal in the interaction of T cells with the functional components of tissue allografts that are epithelial in origin. 

Role of Innate Immune Response in Allotransplant Rejection 

Until recently, most of the attention regarding allograft rejection focused on T cells and acquired immune response. Pattern recognition receptors (PRRs), which sense conserved pathogen-derived molecules that differentiate infectious nonself from self 

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