Rejection allotransplant

Role of Innate Immune Response in Allotransplant Rejection... 

Cyclosporine is an important drng in preventing rejection after kidney, liver, heart and other organ transplantation (Haberal et al., 2004). Cyclosporine nsnally is combined with other immnnosnppressives especially glncocorticoids and either azathioprine or mycophenolate mofetil and sirolimns (Krensky et al., 2005). In renal allotransplants it has improved graft acceptance in most clinics to 95 percent. In addition to its nse in transplantation cyclosporine is used for the treatment of a number of autoimmune diseases. In autoimmune diseases, as might be anticipated, cyclosporine is most effective in those which are T cell mediated. These include several forms of psoriasis, rheumatoid arthritis refractive to all other therapy, uveitis, nephrotic syndrome and type I diabetes meUitus. 

Rijksen JF, Koolen MI, Walaszewski JE et al (1982) Vascular complications in 400 consecutive renal allotransplants. J Cardiovasc Surg (Torino) 23 91-98 Sadowski EA, Fain SB, Alford SK et al (2005) Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging initial experience. Radiology 236 911-919... 

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