Roche Vitamins Fine Chemicals

Roche Vitamins Fine Chemicals (Switzerland) Schweizerhall (Switzerland)... 

Roche Vitamins Fine Chemicals/Div. of Hoffhian Laroche Inc. 

Hoffmann-La Roche (Roche) Strong and early efforts to integrate enantioselective catal3d ic steps in the synthesis of chiral vitamins, fine chemicals, and pharmaceuticals. Development of a proprietary family of biphenyl diphosphine ligands (biphep) many pilot and bench-scale processes. Ligands licensed to PPG-Sipsy and Solvias. 

Fine chemical companies are generally either small and privately held or divisions of larger companies, such as Eastman Fine Chemicals (United States) and Lonza (Switzerland). Examples of large public fife science companies, which market fine chemicals as a subsidiary activity to their production for captive use, are Hoffmann-La Roche, Sandoz, and Boehringer Ingelheim, which produce and market bulk vitamins and liquid crystal intermediates, dyestuff intermediates, and bulk active ingredients, respectively. Table 3 fists some representative companies having an important fine chemical business. 

G reeff http //www. pechiney-chemicals. com RIA Int l. http //www.riausa.com] Richard s Pacific Chem. Sourcing Roche Vitamins http //www.roche.com/vitamins] Rochem Int l. Ruger http //www. rugerchemicai. com SOCO-Lynch Seltzer http //WWW.seitzerchemicais. com Si gma Southchem Spectrum Quality Prods. http //www.spectrumchemicai. com Stason Pharmaceuticals Synasia Fine Chem. http //www.synasia.com] Takeda Am. Takeda UK Textile Chem. http //www.textiiechem.com Triple Crown Am. 

Catalytic hydrogenation is unquestionably the workhorse of catalytic organic synthesis, with a long tradition dating back to the days of Sabatier [53] who received the 1912 Nobel Prize in Chemistry for his pioneering work in this area. It is widely used in the manufacture of fine and specialty chemicals and a special issue of the journal Advanced Synthesis and Catalysis was recently devoted to this important topic [54]. According to Roessler [55], 10-20% of all the reaction steps in the synthesis of vitamins (even 30% for vitamin E) at Hoffmann-La Roche (in 1996) are catalytic hydrogenations. 

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