Robust experimentation

Given robust experimental evidence of cannabis withdrawal, recent interest has focused on the extent to which medications may assist in the amelioration... 

Huth JR, Mendoza R, OlejniczakET, etal. (2005) ALARM NMR A rapid and robust experimental method to detect reactive false positives in biochemical screens. /. Am. Chem. Soc. 127 217-224. 

Analysis of split-plot designs for robust experimentation... 

One way to circumvent issues with generating and maintaining multivariate calibrations is to use first-principle kinetic models that are fit to robust experimental data. This... 

A characteristic of this type of reactor is the steel substrate, which is preferably used as the reaction chamber (it can also be titanium or aluminum). This allows the use of microstructures under robust experimental conditions such as high temperatures. 

These are exciting times in the field of chemosensory reception in general and olfaction in particular. In the decade since the landmark identification of a novel class of candidate odorant receptors (ORs) in rats (Buck and Axel, 1991), we have seen an explosion of similar studies involving other vertebrate as well as several insect species. In addition to an ever-increasing wealth of behavioral and physiological studies, insect systems provide arguably the most robust experimental system for the study of olfaction as well as a profound demonstration of the universal conservation of olfactory signal transduction mechanisms. 

Robustness Experimental design establishing the changing critical parameters (e.g. mobile phase composition, column temperature). 

The concept of parity in scaling up or down implies that the performance features, selectivity behavior, and recyclability of the stationary phase material used for the analytical and the preparative separation are identical, with the exception of particle size. Both robust experimental methods as well as rules of thumb, acquired by experienced investigators, have been developed that enable such comparisons to be made. An extensive scientific literature is now available to indicate sound foundations for such scaling up strategies, coupled with suitable experimental methods for their validation. Table 1 summarizes some of this information. 

Fig. 15 Schematic illustration of different robust experimental designs (A) Taguchi design and (B) response surface design. (View this art in color at WWW. dekker. com.)...

Mechanistic data for cancer are considered in hazard characterization in the context of mode of induction of toxic effects. A postulated mode of action is a biologically plausible sequence of key events leading to an observed effect supported by robust experimental observations and mechanistic data. It describes key cytologi-cal, genetic, and biochemical events— that is, those that are both measurable and necessary to the observed effect. Mode of action is contrasted with mechanism of action, which generally involves a much greater understanding of the molecular basis for an effect. 

Very early on, the principal DSTO researchers realised they needed a new way of looking at this problem and came up with iimovative ways to classify the S T and ways to measure the effect on the subject. The analysis was more innovative than the technology (gadgets) at that stage. A robust experimental methodology was needed in order to be able to assess the soldier as part of the combat system, to identify any key technology areas that would enhance future combat effectiveness and to populate the developed computer war games. 

A robust experimental concept potentially apphcable to all time domains is the feedback-optimized control [21] which requires no knowledge of the underlying mechanism in effecting control. Optimal control theory [187] provides theoretical and computational description of the process to help understand the control mechanisms in effect. 

Genomics for Biosafety in Plant Biotechnology J. Lewis, J.M. Baker, M.H. Beale and J.L. Ward, Metabolite Profiling of GM Plants The Importance of Robust Experimental Design and Execution , p. 47... 

PLP-SEC has proven to be a very simple and robust experimental technique for determining kp and its temperature dependence, provided adequate care is taken with SEC analysis. Data collected from various research laboratories around the world have been compiled in a series of papers for styrene [11] and methacrylates [12-14]. These papers provide benchmark kp data for these monomer systems, illustrate the good agreement between facilities (typically 10-20%), and make recommendations for best experimental practices. 

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